See a complete PubMed list of publications by George Liu, MD, PhD.

Selected Key Publications

Kolar S, Kyme P, Tseng CW, Soliman A, Kaplan A, Liang J, Nizet V, Jiang D, Murali R, Arditi M, Underhill DM, Liu GY. Group B Streptococcus evades host immunity by degrading hyaluronan. Cell Host Microbe. 2015;18(6):694-704.

Tseng CW, Biancotti JC, Berg BL, Gate D, Kolar SL, Muller S, Rodriguez MD, Rezai-Zadeh K, Fan X, Beenhouwer DO, Town T, Liu GY. Increased susceptibility of humanized NSG mice to Panton-Valentine leukocidin and Staphylococcus aureus skin infection. PLOS Pathog. 2015;11(11):e1005292.

Sabrina Müller, Wolf AJ, Iliev ID, Berg BL, Underhill DM, Liu GY. Poorly cross-linked peptidoglycan in MRSA due to mecA induction activates the inflammasome and exacerbates immunopathology. Cell Host Microbe. 2015;18(5):604-612.

Tseng CW, Liu GY. Expanding roles of neutrophils in aging hosts. Curr Opin Immunol. 2014 Aug;29:43-48.

Kyme P, Thoennissen NH, Tseng CW, Iwanski GB, Shimada K, Krug UO, Lee K, Hardy WD, Gombart AF, Koeffler HP, Liu GY. C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice. J Clin Invest. 2012;122(9):3316-3329.

Park B, Liu GY. Targeting the host-pathogen interface for treatment of Staphylococcus aureus infection. Sem Immunopath. 2012;34(2):299-315.

Shimada T, Park B, Goodridge HS, Wolf AJ, Becker CA, Reyes CN, Miao EA, Aderem A, Götz F, Liu GY, Underhill DM. Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation and IL-1beta secretion. Cell Host Microbe. 2010;7(1):38-49.

Tseng CW, Kyme P, Low J, Rocha MA, Alsabeh R, Miller LG, Otto M, Arditi M, Diep BA, Nizet V, Doherty TM, Beenhouwer DO, Liu GY. Staphylococcus aureus Panton-Valentine leukocidin contributes to inflammation and muscle tissue injury. PLOS ONE. 2009;4(7):e6837.

Liu GY, Nizet V. Color me bad: microbial pigments as virulence factors. Trends Microbiol. 2009;17(9):406-413.

Liu C-I, Liu GY, Song Y, Yin F, Hensler ME, Nizet V, Wang AH, Oldfield E. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science. 2008;319(5868):1391-1394.

Park B, Nizet V, Liu GY. Role of Staphylococcus aureus catalase in niche competition against Streptococcus pneumoniae. J Bacteriol. 2008;190(7):2275-2278.

Liu GY, Essex A, Buchanan JT, Datta V, Fierer J, Nizet V. Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity. J Exp Med. 2005;202(2):209-215.

Liu GY, Doran K, Lawrence T, Turkson N, Puliti M, Tissi L, Nizet V. Sword and shield: linked group B streptococcal β-hemolysin/cytolysin and carotenoid pigment function to subvert host phagocyte defense. Proc Natl Acad Sci USA. 2004;101(40):14491-14496.

Doran K., Liu GY, Nizet V. Group B streptococcal β-hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis. J Clin Invest. 2003;112(5):736-744.

Liu, GY, Fairchild, PJ, Smith, RM, Prowle, JR, Koussis, D, Wraith, DC. Low avidity recognition of self-antigen by T cells permits escape from central tolerance. Immunity. 1995;3(4):407-415.