Publications

Zhou C, Tong Y, Wawrowsky K, Melmed S. PTTG acts as a STAT3 target gene for colorectal cancer cell growth and motility. Oncogene. 2013 Feb 18. doi: 10.1038/onc.2013.16.

Fukuoka H, Cooper O, Ben-Shlomo A, Mamelak A, Ren SG, Bruyette D, Melmed S. EGFR as a therapeutic target for human, canine, and mouse ACTH-secreting pituitary adenomas. J Clin Invest. 2011 Dec;121(12):4712-4721.

Tong Y, Zhou J, Mizutani J, Fukuoka H, Ren SG, Gutierrez-Hartmann A, Koeffler HP, Melmed S.  CEBPD suppresses pituitary prolactin expression and lactotroph proliferation.  Mol Endocrinol. 2011 Nov;25(11):1880-1891.

Liu NA, Jiang H, Ben-Shlomo A, Wawrowsky K, Fan XM, Lin S, Melmed S. Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (CDK) inhibitor. Proc Natl Acad Sci USA. 2011 May 17;1808(20):8414-8419.

Melmed S. Acromegaly pathogenesis and treatment. J Clin Invest. 2009 Nov;119(11):3189-3202.

Ben-Shlomo A, Schmid H, Wawrowsky K, Pichurin O, Hubina E, Chesnokova V, Liu NA, Culler M, Melmed S. Differential ligand-mediated pituitary somatostatin receptor subtype signaling: Implications for corticotroph tumor therapy. J Clin Endocrinol Metab. 2009 Nov; 94(11):4342-4350.

Chesnokova V, Zonis S, Kovacs K, Ben-Shlomo A, Wawrowsky K, Bannykh S, Melmed S. p21(Cip1) restrains pituitary tumor growth. Proc Natl Acad Sci USA. 2008 Nov 11;105(45):17498-17503.

Ben-Shlomo A, Wawrowsky KA, Proekt I, Wolkenfeld NM, Ren SG, Taylor J, Culler MD, Melmed S.  Somatostatin receptor type 5 modulates somatostatin receptor type 2 regulation of ACTH secretion. J Biol Chem. 2005 Jun 24; 280(25):24011-24021.

Murray RD, Kim K, Ren SG, Chelly M, Umehara Y, Melmed S. Central and peripheral actions of somatostatin on the growth hormone-IGF-I axis. J Clin Invest. 2004 Aug;114(3):349-356.

Heaney AP, Horwitz GA, Wang Z, Singson R, Melmed S. Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis. Nat Med. 1999 Nov;5(11):1317-1321.

Chesnokova V, Zhou C, Zonis S, Tani Y, Ben-Shlomo A, Ren SG, Melmed S. Growth hormone is a cellular senescence target in pituitary and non-pituitary cells. Proc Natl Acad Sci USA. 2013 Aug;110(35):E3331-9. doi: 10.1073/pnas.1310589110.

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