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Structural Biology and Molecular Therapeutics
Research at the Murali Laboratory focuses on defining the molecular basis of drug resistance mechanisms and cancer metastasis, and on developing new targeted therapeutic drugs. To learn the interplay between immunity and cancer, studies are focused on the role of the tumor necrosis factor receptors and the epidermal growth factor receptors in breast, lung and pancreatic cancers. We employ protein engineering, X-ray diffraction, molecular biology and computational biology for drug discovery and for developing molecular probes for tumor imaging and drug delivery.