Research in the Noble Laboratory focuses on cellular and molecular mechanisms of lung inflammation and fibrosis, the role of lung stem cells in pulmonary fibrosis and the role of host defense in lung inflammation and fibrosis. We have clinical expertise in interstitial lung disease and are conducting clinical trials in idiopathic pulmonary fibrosis, bronchiolitis and pulmonary disease related to connective tissue disease. The Noble Laboratory is generously supported by the National Heart, Lung and Blood Institute at the National Institutes of Health.
Classic usual interstitial pneumonia. A) Chest CAT scan demonstrating the cardinal radiographic features of IPF: subpleural honeycombing, traction bronchiectasis and thickened interlobular septae. B) Lung biopsy demonstrating the cardinal pathologic manifestations of UIP: a variegated pattern of chronic interstitial fibrosis, subpleural accentuation and fibroblastic foci. C) Lung biopsy demonstrating a fibroblast focus without accompanying inflammation. From J Clin Invest. Aug 1, 2012; 122(8): 2756–2762.