Click here for a complete list of David Quan Shih, MD, PhD publications.

Selected Key Publications

Shih DQ, Bussen M, Sehayek E, Ananthanarayanan M, Shneider BL, Suchy FJ, Shefer S, Bollileni JS, Gonzalez FJ, Breslow JL, Stoffel M. Hepatocyte nuclear factor-1a is an essential regulator of bile acid and plasma cholesterol metabolism. Nat Genet. 2001;27:375-82.

Kulkarni RN, Holzenberger M, Shih DQ, Ozcan U, Stoffe lM, Magnuson MA, Kahn CR. Beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet. 2002;31:111-5.

Shih DQ, Heimesaat M,Kuwajima S, Stein R, Wright CV, Stoffel M. Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta. Proc NatlAcadSci USA. 2002;99:3818-23.

Wolfrum C, Shih DQ, Kuwajima S, Norris AW, Kahn CR, Stoffel M. Role of Foxa-2 in adipocyte metabolism and differentiation. J Clin Invest. 2003;112(3):345-356.

Shih DQ, Targan SR. Insights into IBD pathogenesis. Current Gastroenterology Reports. 2009;11:473-80.

Shih DQ, Kwan LY, et al. Induction of inflammatory bowel disease associated gene TL1A (TNFSF15) by microbes in antigen presenting cells. European Journal of Immunology. 2009;39(11):3239-3250.

Shih DQ, Barrett R, et al. Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis. PLoS One. 2011;6(1):1-16. 

Koon HW, Shih DQ, et al. Cathelicidin signaling via the Toll-like receptor protects against colitis in mice. Gastroenterology. 2011;141(5):1852-1863.

Shih DQ, Nguyen M, et al. Split-dose administration of thiopurine drugs: a novel and effective strategy for managing preferential 6-MMP metabolism. Alimentary Pharmacology & Therapeutics. 2012;36(5):449-58.

Barrett R, Zhang X, Koon HW, Vu M, Chang JY, Yeager N, Nguyen MA, Michelsen KS, Berel D, Pothoulakis C, Targan SR, Shih DQ. Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis. American Journal of Pathology.2012;180(2):636-49. PMID: 22138299.

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