Publications

See a complete PubMed list of publications by David Quan Shih, MD, PhD.

Selected Key Publications

Zhang H, Wu H, Liu L, Li H, Shih DQ, Zhang X. 1,25-dihydroxyvitamin D3 regulates the development of chronic colitis by modulating both T helper (Th)1 and Th17 activation. APMIS. 2015 Jun;123(6):490-501. http://onlinelibrary.wiley.com/doi/10.1111/apm.12378/abstract.

Amin J, Huang B, Yoon J, Shih DQ. Update 2014: advances to optimize 6-mercaptopurine and azathioprine to reduce toxicity and improve efficacy in the management of IBD. Inflamm Bowel Dis. 2015 Feb;21(2):445-452. http://journals.lww.com/ibdjournal/Fulltext/2015/02000/Update_2014___Advances_to_Optimize.25.aspx.

Shih DQ, Zheng L, Zhang X, Zhang H, Kanazawa Y, Ichikawa R, Wallace KL, Chen J, Pothoulakis C, Koon HW, Targan SR. Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis. Mucosal Immunol. 2014 Nov;7(6):1492-1503. http://www.nature.com/mi/journal/v7/n6/full/mi201437a.html.

Hing TC, Ho S, Shih DQ, Ichikawa R, Cheng M, Chen J, Chen X, Law I, Najarian R, Kelly CP, et al. The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice. Gut 2013 Sep;62(9):1295-1305. http://gut.bmj.com/content/62/9/1295.

Barrett R, Zhang X, Koon HW, Vu M, Chang JY, Yeager N, Nguyen MA, Michelsen KS, Berel D, Pothoulakis C, Targan SR, Shih DQ. Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis. Am J Pathol. 2012;180(2):636-649. http://ajp.amjpathol.org/article/S0002-9440(11)01018-2/abstract.

Shih DQ, Nguyen M, Zheng L, Ibanez P, Mei L, Kwan LY, Bradford K, Ting C, Targan SR, Vasiliauskas EA. Split-dose administration of thiopurine drugs: a novel and effective strategy for managing preferential 6-MMP metabolism. Aliment Pharmacol Ther. 2012;36(5):449-458. http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2012.05206.x/abstract.

Koon HW, Shih DQ, Chen J, Bakirtzi K, Hing TC, Law I, Ho S, Ichikawa R, Zhao D, Xu H, et al. Cathelicidin signaling via the Toll-like receptor protects against colitis in mice. Gastroenterology 2011;141(5):1852-1863. http://www.gastrojournal.org/article/S0016-5085(11)00934-6/abstract.

Shih DQ, Barrett R, Zhang X, Yeager N, Koon HW, Phaosawasdi P, Song Y, Ko B, Wong MH, Michelsen KS, et al. Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis. PLOS One. 2011;6(1): e16090. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016090.

Shih DQ, Kwan LY, Chavez V, Cohavy O, Gonsky R, Chang EY, Chang C, Elson CO, Targan SR. Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells. Eur J Immunol. 2009;39(11):3239-3250. http://onlinelibrary.wiley.com/doi/10.1002/eji.200839087/abstract.

Shih DQ, Targan SR. Insights into IBD pathogenesis. Curr Gastroenterol Rep. 2009;11(6):473-480. http://link.springer.com/article/10.1007/s11894-009-0072-9.

Wolfrum C, Shih DQ, Kuwajima S, Norris AW, Kahn CR, Stoffel M. Role of Foxa-2 in adipocyte metabolism and differentiation. J Clin Invest. 2003;112(3):345-356. http://www.jci.org/articles/view/18698.

Shih DQ, Heimesaat M, Kuwajima S, Stein R, Wright CV, Stoffel M. Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta. Proc Natl Acad Sci USA. 2002;99(6):3818-3823. http://www.pnas.org/content/99/6/3818.abstract?sid=96a4de99-0990-4a2d-a76b-ae644ad01d28.

Kulkarni RN, Holzenberger M, Shih DQ, Ozcan U, Stoffe lM, Magnuson MA, Kahn CR. Beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet. 2002;31(1):111-115. http://www.nature.com/ng/journal/v31/n1/abs/ng872.html.

Shih DQ, Bussen M, Sehayek E, Ananthanarayanan M, Shneider BL, Suchy FJ, Shefer S, Bollileni JS, Gonzalez FJ, Breslow JL, Stoffel M. Hepatocyte nuclear factor-1a is an essential regulator of bile acid and plasma cholesterol metabolism. Nat Genet. 2001;27(4):375-382. http://www.nature.com/ng/journal/v27/n4/abs/ng0401_375.html.

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