Publications

See a complete PubMed list of publications by Clive Svendsen, PhD.


Selected Key Publications

Das MM, Avalos P, Suezaki P, Godoy M, Garcia L, Chang CD, Vit JP, Shelley B, Gowing G, Svendsen CN. Human neural progenitors differentiate into astrocytes and protect motor neurons in aging rats. Exp Neurol. 2016 Jun;280:41-49. http://www.sciencedirect.com/science/article/pii/S001448861630067X.

Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, Livesey MR, Lowry E, Macklis JD, Rushton D, Sadegh C, Sareen D, Wichterle H, Zhang SC, Svendsen CN. Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nat Neurosci. 2016 Mar 29;16(4):542-553. http://www.nature.com/neuro/journal/v19/n4/full/nn.4273.html.

Suzuki M, Svendsen CN. Ex vivo gene therapy using human mesenchymal stem cells to deliver growth factors in the skeletal muscle of a familial ALS rat model. Methods Mol Biol. 2016;1382:325-336. http://link.springer.com/protocol/10.1007%2F978-1-4939-3271-9_24.

Thomsen GM, Vit JP, Lamb A, Gowing G, Shelest O, Alkaslasi M, Ley EJ, Svendsen CN. Acute traumatic brain injury does not exacerbate amyotrophic lateral sclerosis in the SOD1 (G93A) rat model(1,2,3). eNeuro. 2015;2(3). pii: ENEURO.0059-14.2015. http://eneuro.org/content/2/3/ENEURO.0059-14.2015.

Mattis VB, Svendsen CN. Modeling Huntington's disease with patient-derived neurons. Brain Res. 2015 Oct 13. pii: S0006-8993(15)00738-6. [Epub ahead of print.] http://www.sciencedirect.com/science/article/pii/S0006899315007386.

Straccia M, Garcia-Diaz Barriga G, Sanders P, Bombau G, Carrere J, Mairal PB, Vinh NN, Yung S, Kelly CM, Svendsen CN, et al. Quantitative high-throughput gene expression profiling of human striatal development to screen stem cell-derived medium spiny neurons. Mol Ther Methods Clin Dev. 2015 Sep 16;2:15030. http://www.nature.com/articles/mtm201530.

Levy M, Boulis N, Rao M, Svendsen CN. Regenerative cellular therapies for neurologic diseases. Brain Res. 2016 May 1;1638(Pt A):88-96. [Epub ahead of print.] http://www.sciencedirect.com/science/article/pii/S0006899315005843.

Hatada S, Subramanian A, Mandefro B, Ren S, Kim HW, Tang J, Funari V, Baloh RH, Sareen D, Arumugaswami V, Svendsen CN. Low-dose irradiation enhances gene targeting in human pluripotent stem cells. Stem Cells Transl Med. 2015;4(9):998-1010. http://stemcellstm.alphamedpress.org/content/4/9/998.

Bernau K, Lewis CM, Petelinsek AM, Reagan MS, Niles DJ, Mattis VB, Meyerand ME, Suzuki M, Svendsen CN. In vivo tracking of human neural progenitor cells in the rat brain using magnetic resonance imaging is not enhanced by ferritin expression. Cell Transplant. 2015 Jul 8. [Epub ahead of print.] http://www.ingentaconnect.com/contentone/cog/ct/2016/00000025/00000003/art00013.

Gutierrez J, Lamanna JJ, Grin N, Hurtig CV, Miller JH, Riley J, Urquia L, Avalos P, Svendsen CN, et al. Preclinical validation of multilevel intraparenchymal stem cell therapy in the porcine spinal cord. Neurosurgery. 2015;77(4):604-612. http://journals.lww.com/neurosurgery/Abstract/2015/10000/Preclinical_Validation_of_Multilevel.22.aspx.

Tsai Y, Lu B, Bakondi B, Girman S, Sahabian A, Sareen D, Svendsen CN, Wang S. Human iPSC-derived neural progenitors preserve vision in an AMD-like model. Stem Cells. 2015 Aug;33(8):2537-2549. http://onlinelibrary.wiley.com/doi/10.1002/stem.2032/abstract.

Mattis VB, Tom C, Akimov S, Saeedian J, Østergaard ME, Southwell AL, Doty CN, Ornelas L, Sahabian A, Lenaeus L, Mandefro B, Sareen D, Arjomand J, Hayden MR, Ross CA, Svendsen CN. HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity. Hum Mol Genet. 2015;24(11):3257-3271. http://hmg.oxfordjournals.org/content/24/11/3257.

Kong SY, Park MH, Lee M, Kim JO, Lee HR, Han BW, Svendsen CN, Sung SH, Kim HJ. Kuwanon V inhibits proliferation, promotes cell survival and increases neurogenesis of neural stem cells. PLOS One. 2015;10(2):e0118188. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118188.

Lu B, Lin Y, Tsai Y, Girman S, Adamus G, Jones MK, Shelley B, Svendsen CN, Wang S. A subsequent human neural progenitor transplant into the degenerate retina does not compromise initial graft survival or therapeutic efficacy. Transl Vis Sci Technol. 2015;4(1):7. http://tvst.arvojournals.org/article.aspx?articleid=2212987.

Lu XH, Mattis VB, Wang N, Al-Ramahi I, van den Berg N, Fratantoni SA, Waldvogel H, Greiner E, Osmand A, Elzein K, Xiao J, Dijkstra S, de Pril R, Vinters HV, Faull R, Signer E, Kwak S, Marugan JJ, Botas J, Fischer DF, Svendsen CN, et al. Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease. Sci Transl Med. 2014;6(268):268ra178. http://stm.sciencemag.org/content/6/268/268ra178.

Das MM, Svendsen CN. Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS. Neurobiol Aging. 2015;36(2):1130-1139. http://www.neurobiologyofaging.org/article/S0197-4580(14)00625-3/abstract.

Thomsen GM, Gowing G, Latter J, Chen M, Vit JP, Staggenborg K, Avalos P, Alkaslasi M, Ferraiuolo L, Likhite S, Kaspar BK, Svendsen CN. Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex. J Neurosci. 2014;34(47):15587-15600. http://www.jneurosci.org/content/34/47/15587.

Barrett R, Ornelas L, Yeager N, Mandefro B, Sahabian A, Lenaeus L, Targan SR, Svendsen CN, Sareen D. Reliable generation of induced pluripotent stem cells from human lymphoblastoid cell lines. Stem Cells Transl Med. 2014;3(12):1429-1434. http://stemcellstm.alphamedpress.org/content/3/12/1429.

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