See a complete PubMed list of publications by David Underhill, PhD.

Selected Key Publications

Wheeler ML, Limon JJ, Underhill DM. Immunity to commensal fungi: detente and disease. Annu Rev Pathol. 2017 Jan 24;12:359-385.

Wolf AJ, Liu GY, Underhill DM. Inflammatory properties of antibiotic-treated bacteria. J Leukoc Biol. 2017 Jan;101(1):127-134.

Wolf AJ, Reyes CN, Liang W, Becker C, Shimada K, Wheeler ML, Cho HC, Popescu NI, Coggeshall KM, Arditi M, Underhill DM. Hexokinase is an innate immune receptor for the detection of bacterial peptidoglycan. Cell. 2016 Jul 28;166(3):624-636.

Wheeler ML, Limon JJ, Bar AS, Leal CA, Gargus M, Tang J, Brown J, Funari VA, Wang HL, Crother TR, Arditi M, Underhill DM, Iliev ID. Immunological consequences of intestinal fungal dysbiosis. Cell Host Microbe. 2016 Jun 8;19(6):865-873.

Underhill DM, Pearlman E. Immune interactions with pathogenic and commensal fungi: a two-way street. Immunity. 2015 Nov 17;43(5):845-858.

Müller S, Wolf AJ, Iliev ID, Berg BL, Underhill DM, Liu GY. Poorly cross-linked peptidoglycan in MRSA due to mecA induction activates the inflammasome and exacerbates immunopathology. Cell Host Microbe. 2015 Nov 11;18(5):604-612.

Underhill DM, Iliev ID. The mycobiota: interactions between commensal fungi and the host immune system. Nat Rev Immunol. 2014 Jun;14(6):405-416.

Ma J, Becker C, Reyes C, Underhill DM. Cutting edge: FYCO1 recruitment to dectin-1 phagosomes is accelerated by light chain 3 protein and regulates phagosome maturation and reactive oxygen production. J Immunol. 2014 Feb 15;192(4):1356-1360.

Iliev ID, Funari VA, Taylor KD, Nguyen Q, Reyes CN, Strom SP, Brown J, Becker CA, Fleshner PR, Dubinsky M, Rotter JI, Wang HL, McGovern DPB, Brown GD, Underhill DM. Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis. Science. 2012;336(6086):1314-1317.

Kaplan A, Ma J, Kyme P, Wolf AJ, Becker CA, Tseng CW, Liu GY, Underhill DM. Failure to induce interferon-beta production during Staphylococcus aureus infection contributes to pathogenicity. J Immunol. 2012;189(9):4537-4545.

Ma J, Becker C, Lowell CA, Underhill DM. Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens. J Biol Chem. 2012 Oct 5;287(41):34149-34156.

Underhill DM, Goodridge HS. Information processing during phagocytosis. Nat Rev Immunol. 2012 Jul 1;12:492-502.

Wolf AJ, Arruda A, Reyes CN, Kaplan AT, Shimada T, Shimada K, Arditi M, Liu G, Underhill DM. Phagosomal degradation increases TLR access to bacterial ligands and enhances macrophage sensitivity to bacteria. J Immunol. 2011;187(11):6002-6010.

Goodridge HS, Reyes CN, Becker CA, Katsumoto TR, Ma J, Wolf AJ, Bose N, Chan A, Magee AS, Danielson ME, Weiss A, Vasilakos JP, Underhill DM. Activation of the innate immune receptor Dectin-1 upon formation of a "phagocytic synapse." Nature. 2011;472(7344):471-475.

Shimada T, Park B, Wolf AJ, Brikos C, Goodridge HS, Becker CA, Reyes CN, Miao EA, Aderem A, Götz F, Liu GY, Underhill DM. Staphylococcus aureus evades the lysozyme-based digestion of peptidoglycan that links phagocytosis and macrophage IL-1 secretion. Cell Host and Microbe. 2010;7(1):38-49.