Lee is a research scientist at Cedars-Sinai's Department of Neurosurgery. His research areas include design and development of nanometer-sized drug/prodrug and drug delivery systems; targeted cancer therapy using nanodrugs/nanoprodrugs; targeted cancer immunotherapy using B7-H1 inhibitory nanoprodrugs; targeted treatment of Alzheimer's disease using anti-inflammatory nanoprodrugs; and development of imaging and diagnostic agents using nanoparticles. His recent research is focused on targeted therapies for brain tumors, breast cancer, and pancreatic cancer using oxidative stimuli-sensitive camptothecin nanoprodrug and anti-immunosuppressive nanoprodrugs that are able to pass through the blood-brain barrier and selectively accumulate in tumor tissues. Lee earned his bachelor's and master's degrees in chemistry from the University of Technology in Darmstadt, Germany. He earned his doctorate in biochemistry from the University of Regensburg, Germany.
Lee is a research scientist in the Cedars-Sinai Department of Neurosurgery. His research is focused on the mechanism of communication between the cancer stem cell (CSC) and its microenvironment in brain glioblastoma multiforme. His focus is on learning how CSCs maintain their self-renewal and multipotency in brain cancer, and how their functions differ from the functions of neural stem cells (NSCs) in the course of brain development. He is looking for molecular mechanisms to explain the stemness of CSCs in relation to the microenvironment, which mutually communicate and affect each other. His work also seeks to identify normal NSCs from an alternative source to develop cellular disease models and apply patient-specific stem cell therapy for neurological diseases. Lee earned his PhD at the University of Connecticut in Storrs and completed his postdoctoral training at Harvard and Wake Forest Institute in Regenerative Medicine.
Ji is a research scientist focused on translating the lab's basic research findings into clinical trials. His research focuses on cancer immunotherapy - specifically, the development of dendritic cell-based vaccines. These DC vaccines target not only brain tumor cells expressing specific tumor-associated antigens, but also cancer stem cells. Ji received his PhD from Clemson University and completed his postdoctoral training at City of Hope Medical Center.
Zhang is a project scientist at Cedars-Sinai's Department of Neurosurgery. His research focuses on glioma stem cells and dendritic immunotherapy. He is planning to apply stem cell specific cytotoxic T lymphocytes to target glioma stem cells to prevent the recurrence of malignant glioma. Zhang earned his bachelor's degree from China Medical University and his PhD from the University of Yamanashi, Japan. He received his postdoctoral training at the University of Calgary, Canada, and Mayo Clinic, Rochester.
Li is a project scientist in the Maxine Dunitz Neurosurgical Institute and the Department of Neurosurgery at Cedars-Sinai. His research focuses on translating basic research on cancer stem cells and immunotherapy targeting cancer stem cells into innovative therapies for cancer patients. He graduated with a PhD in biopharmaceutics from China Pharmaceutical University and performed multidisciplinary research at universities in the United States.
Amano is a postdoctoral scientist at Cedars-Sinai's Department of Neurosurgery. Before joining Cedars-Sinai, he spent 10 years as a neurosurgeon at Yamaguchi University Hospital, Japan. Amano specializes in brain tumors; his research areas include immunotherapy against glioblastoma (and/or cancer stem cell derived from glioblastoma) using dendritic cells.
Kim is a postdoctoral scientist at Cedars-Sinai's Department of Neurosurgery. His research focuses on immune therapy of the cancer stem cells. Kim received his bachelor's degree in biomedical science from Hallym University, South Korea. He earned his MS and PhD in pharmacology at Hallym University Graduate School of Medical Science, South Korea.
Wang is currently a research associate III at Cedars-Sinai's Department of Neurosurgery and works as a clinical trial team member. His main research area is manufacturing vaccines for brain tumor patients and monitoring their immune responses to assess the efficacy of vaccines for the treatment of brain tumor. Wang earned his MD at Shanghai Medical University (now Shanghai Medical School of Fudan University) and joined Cedars-Sinai in 2008.
Edwards, PhD is a project scientist in the Department of Neurosurgery. His research is concerned with the identification of brain cancer molecular markers that may be used as diagnostic tools. The challenge is to find new molecular markers or signatures that alone or in combination result in improved benefits in risk assessment, patient prognosis and that may ultimately aid in determining targeted therapies to combat brain cancer. Edwards earned his PhD at the University of British Columbia, Canada. He completed his postdoctoral training at the National Institutes of Health in the Neuro-Oncology Branch in Bethesda, Maryland.
Xu is a research associate in the Department of Neurosurgery. She is currently working on a dendrite cell-based immunotherapy clinical trial, human brain tumor cell primary culture establishment, and brain tumor stem cell culture. Xu earned her bachelor's and master's degrees in medicine at Zhejiang University. She is currently a PhD candidate at the College of Life Science, Zhejiang University.
Liu is a research associate at Cedars-Sinai's Department of Neurosurgery. Her research uses cell and molecular biology techniques to work with a gene therapy research project. Liu earned her bachelor's degree at Jinan University, Medical School, China. She worked and trained at Johns Hopkins Hospital for over 10 years before joining Yu Laboratory.