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On clinical imaging research side, the Zhou Laboratory focuses on investigating image quality optimization with balanced radiation dose. The current studies include digital mammography, computed tomography and fluoroscopy. In digital mammography, the focus is on finding practical methodologies to assess the performance of automatic exposure control (AEC). For computed tomography, I have studied the impact of adaptive statistical reconstruction to image quality. I am interested in seeking optimal techniques for different sizes of patients from the physics perspective. Another goal is to investigate the potential of quantifying organ dose by extracting measurable dose during clinical CT acquisitions.
For the preclinical imaging, I am interested in quantitative methodologies, such as the impact of attenuation correction and scatter reduction to microPET/SPECT imaging. The scientific investigation of characterizing vulnerable plaque in animals is of high interest. Given that the plaque buildup is small, the molecular imaging signal in the lipid core becomes important. Another related project is simulation of coronary artery blood flow, especially the relationship of fractional flow reserve (FFR) and pre-existing infarct size.