Spencer L. SooHoo, PhD

Director, Research Informatics and Scientific Computing Core

Faculty, Division of Informatics, Department of Biomedical Sciences

Research Profile

Spencer L. SooHoo, PhD, is the director of the Research Informatics and Scientific Computing Core at Cedars-Sinai and is on the faculty of the Division of Informatics, Department of Biomedical Sciences. Dr. SooHoo has a wide range of range of information technology experience, having served as an Information Technology infrastructure director at Cedars-Sinai for over 10 years. He was also both the director, Scientific Computing and Chief Security Officer for 8 years before focusing solely on research informatics.

As the site bioinformatics program leader for the UCLA-CTSI, he helped launch Los Angeles Data Network (LADR), a Distributed Clinical Data Research Network (CDRN) that provides researchers access to aggregated Electronic Health Record (EHR) data from Southern California institutions including Cedars-Sinai, UCLA, and USC. He is also the site PI for the PCORI-funded pSCANNER network and led a project to connect Cedars-Sinai to the pSCANNER CDRN. Besides his work on CDRNs, Dr. SooHoo is the PI for a National Institute for Standards and Technology award to pilot the use of a federated identity in healthcare, and is a site Co-PI for the California Precision Medicine Consortium (CaPMC), one of the partners in the NIH-sponsored All of Us Research Program.

His research interests include the construction of CDRNs that allow research use of EHR data while preserving the security of the data and protecting patient privacy. He is also interested in patient identity proofing, privacy preserving record linkage, and the development of tools that can be used to enhance clinical trials recruitment.


  • Bachelor of Science, Electrical Engineering, University of Rochester, Rochester, NY, 1970
  • Master of Science, Electrical Engineering, George Washington University, Washington, DC, 1972
  • Doctorate, Biomedical Engineering, University of Southern California, Los Angeles, CA, 1979

Cedars-Sinai Affiliations

  • Enterprise Information Systems
  • Division of Informatics, Department of Biomedical Sciences


UL1TR000124 Dubinett (PI) 2011-2016
UCLA Clinical Translational Science Institute
Goal: Create an academic home for clinical and translational science that integrates and builds on the many strengths of UCLA and its partners. Build transdisciplinary research teams to accelerate and translate discovery to improve health. Transform educational and career development programs to promote the next generation of clinician investigators and translational scientists. Advance and expand strong bi-directional academic-community partnerships to ensure that new scientific discovery is relevant to community needs. Serve as a national resource for collaborative research through regional, statewide and national CTSA consortia.
Role: Key Personnel, Biomedical Informatics Program

UCSD PCORI CDRN-1306-04819 Sub award 69357720 Ohno-Machado (PI) 2015-2018
Patient-centered SCAlable National Network for Effectiveness Research (pSCANNER)
Goal: Establish a local pSCANNER node to enable Cedars-Sinai to be a data-sharing partner and scientific collaborator in the pSCANNER project.
Role: Site PI

UCLA CTSI Continuation
Award UL1TR001881 Dubinett (PI) 2016-2021
Continuation of the previous CTSI award UL1TR000124
Role: Co-Leader, Informatics

NIST NSTIC Award 70NANB16YH252 SooHoo (PI) 2017-2019
Single Federated Identity Login for Electronic Health Records (Single-FILE).
Goal: Establish a single federated identity access to multiple, independent EHR systems at distinct health care providers. The system will allow both patients and providers to use single-sign-on, a pseudonymous identity, and multifactor authentication and be piloted for at least 6 months, with at least two different healthcare providers.
Role: PI

NIH Award 1OT2OD026552-01 Ohno-Machado (PI) 2018-2023
California Precision Medicine Consortium (All of Us Research Program) Sub award 101612177
Goal: Participate in the All of Us Research Program as a Health Professional Organization and recruit participants for All of Us Research Program. The effort involves outreach as well as providing informatics support to inform the recruitment process and upload data to a central repository.
Role: Site Co-PI


SooHoo, SL, SK Koerner, and HV Brown. 1980. A Comprehensive Pulmonary Data Acquisition System. In: Computers in Critical Care and Pulmonary Medicine, ed. S. Nair. 311-328. New York: Plenum Press.

SooHoo, SL. A FORTH Pulmonary Data Processing System. National Computer Conference, Anaheim, CA. 1980.

SooHoo, SL and HV Brown, 1983. An Algorithm for Computerized Body Plethysmography. Computers in Medicine and Biology. 13:1:1-6.

Jasper, AC, SL SooHoo, and HS Goldberg. Site of Critical Closure in the Canine Pulmonary Vasculature. American Thoracic Society Meeting, May, 1984.

Jasper, AC, SL SooHoo, and HS Goldberg. Critical Closure in the Canine Pulmonary Vasculature. American Thoracic Society Meeting, May, 1986.

Jasper, AC, SL SooHoo, and HS Goldberg. 1986. Relationship of Arterial Wedge Pressure to Closing Pressure in the Pulmonary Circulation. Am Rev Respir Dis 134:879-884.

SooHoo, SL, R Graham, HS Goldberg, AC Jasper. 1987. Zone II and Zone III Pulmonary Blood Flow. J. Appl Physiol. 62(5):1982-88.

SooHoo, SL, F Aabedi, RC Wagnet, M Dorst, M Stempson. The Single Logon Application: An Enabler for Access to Disparate Systems in a Patient-Focused Care Environment. JAMIA Symposium Supplement, SCAMC Proceedings, October,1995.

SooHoo, SL, R Duncan, N Butler, D Jones. A Coherent Strategy for Integrating Clinical Systems. JAMIA Proceedings, November 2001

SooHoo, SL, R Duncan. Lessons Learned from Deployment of Wireless LAN Technology. JAMIA Proceedings, November 2001

Bell, Douglas, Spencer SooHoo, Robert Jenders, Paul Fu, Joshua Lee, Ayan Patel, Marianne Zachariah. The Los Angeles Data Resource (LADR): A Comprehensive Regional Data Resource for Research. AMIA 2014 Joint Summits on Translational Science, April 2014.

Chen, Xi, Gransar, Heidi, Tep, Brian, Miranda-Peats, Romalisa, SooHoo, Spencer, Berman, Daniel. The Evaluation of California Non-Comprehensive Death File Against National Death Index. Annals of Epidemiology. Submitted June 2018.