Osteoarthritis (OA) is one of the most prevalent rheumatic diseases, which affect half the population of the world age 65 or older. OA occurs in multiple forms and is a disease of articular cartilage and bone accompanied by subchondral bone thickening, bony outgrowths and mild chronic nonspecific synovitis. Our research focuses on hand OA, for which little is understood regarding the pathogenesis, but familial aggregation and heritability studies indicate a significant genetic role. We have an ongoing study to assess genetic associations of carefully defined phenotypes of hand OA, classified by specific clinical and radiographic phenotypes. To date, more than 600 subjects with hand OA have participated in our study, and more than 150 siblings have been enrolled. The long-term goal is to advance the understanding of the genetic, molecular and cellular mechanisms involved in hand osteoarthritis.

Program Interactions in Osteoarthritis

  • Cedars-Sinai — Kent Taylor, PhD; Xiuqing Guo, PhD; Myles Cohen, MD; Dermot McGovern, MD, PhD
  • U.S. Centers for Disease Control and Prevention — Rosemarie Hirsch, MD; Charles Dillon, MD
  • UCLA — Roy Altman, MD; Dan Cohn, PhD
  • University of Southern California — Mellissa Withers, PhD