Treatment of each of these conditions focuses upon medication to make the affected organs function better, or transplantation of the organ such as the heart, in the event of heart failure. In patients with the variant forms of transthyretin, a liver transplant is often performed as well to reduce the production of that protein so the new heart or affected nerves do not get further harmed.
In the case of amyloid heart disease, heart transplantation may also be done. We have one of the leading heart transplant centers within the United States and have performed heart transplants for patients with ATTR and AL amyloidosis numerous times. Unfortunately, amyloidosis involving the heart can be quite serious leading to intractable heart failure or even death from an arrhythmia. It is important to be seen by a team of physicians particularly familiar with the issues related to patients with cardiac amyloidosis. In some cases of inherited amyloidosis, liver transplantation can help because it removes the source that produces the mutant protein. We have performed combined heart/liver transplants for patients with ATTR amyloidosis with good success.