Symptoms of DADA2 vary depending on how bad the inflammation is and where it is located. Symptoms may include:
- Repeated fevers on and off
- Tendril-like skin discolorations
- Enlarged liver and spleen
- Recurrent stroke-like episodes
- Immune system abnormalities
Inflammation of the blood vessels (vasculitis) also may cause:
- General aches and pains
- Night sweats
- Weight loss
Causes and Risk Factors
DADA2 is caused by a change in the CECR1 gene, which helps create the protein adenosine deaminase 2. This protein helps support the lining of blood vessel walls.
DADA2 may be diagnosed any time in early childhood or adulthood. For some patients, stroke episodes begin early in childhood and may affect areas deep in the brain.
DADA2 is inherited through a recessive gene, which means both parents of the patient must carry the changed CECR1 gene in order for the patient to have the condition.