Research and Clinical Trials

The Arrhythmia Research Program and Laboratory

The research and clinical trials coordinated by members of The Chugh Laboratory focus on arrhythmia research. The team investigates mechanisms of ventricular arrhythmias with a view to improved prediction, prevention and management of sudden cardiac arrest.

Atrial fibrillation is the most common arrhythmia diagnosis around the globe. One such focused collaborative group, The World Health Organization Global Burden of Atrial Fibrillation Panel, is charged with evaluating the burden of atrial fibrillation in the WHO's 21 regions of the world. Headed by Dr. Sumeet Chugh (Cedars-Sinai Heart Institute), panel members include Dr. Emelia Benjamin (Framingham Heart Study), Dr. Zhi-Jie Zheng (National Heart, Lung and Blood Institute), Dr. Richard Gillum (U.S. CDC) and Dr. George Mensah (U.S. Centers for Disease Control and Prevention).

Additional Discoveries

The Cardiac Arrest Prevention Program

Researchers in the Heart Institute are working to enhance the understanding of mechanisms of sudden cardiac arrest. Despite current advances, the rate of successful resuscitation from sudden cardiac arrest remains low. Our group is searching for novel determinants of this condition that will facilitate the identification of subjects at risk, with the overall goal of improving prevention of sudden cardiac arrest.

The Cardiac Arrest Prevention Program is involved in a variety of ongoing studies at Cedars-Sinai Medical Center and Oregon Health & Science University, as well as several national and international collaborative efforts.

The Oregon Sudden Unexpected Death Study

The Oregon Sudden Unexpected Death Study, initiated and led by Dr. Sumeet Chugh and now in its eighth year, is being conducted in collaboration with the Department of Emergency Medicine at Oregon Health & Science University.

This research effort, currently funded by the National Heart, Blood and Lung Institute, as well as a collaborative grant with the Johns Hopkins Reynolds Cardiovascular Clinical Research Center, is an investigation of sudden cardiac arrests that occur among residents of the Portland, Oregon, metropolitan area. A novel and comprehensive approach of clinical, epidemiologic, environmental, genetic and proteomic analysis is employed to extend and enhance risk stratification and prevention of sudden cardiac death.