Research and Clinical Trials

With the ultimate goal of understanding diabetes, pre-diabetes and related diseases, our DOTEC faculty is actively involved research that spans the spectrum from basic to clinical science. Below is a sample list of publications by our MD scientists.

Vlotides, G., Cooper, O., Chen, Y.H., Ren, S.G., Greenman, Y., and Melmed, S., “Heregulin regulates prolactinoma gene expression”, Cancer Res., 69:4209-16 (2009)

Cooper, O., Ben-Shlomo, A., Bonert, V., Bannykh, S., Mirocha, J., and Melmed, S., “Silent corticogonadotroph adenomas: clinical and cellular characteristics and long term outcomes”, Horm. Cancer, 1:80-92 (2010)

Fukuoka, H., Cooper, O., Mizutani, J., Tong, Y., Ren, S.G., Bannykh, S., and Melmed, S., “HER2/ErbB2 receptor signaling in rat and human prolactinoma cells: strategy for targeted prolactinoma therapy”, Mol. Endocrinol., 25: 92-103 (2011)

Fukuoka, H., Cooper, O., Ben-Shlomo, A., Mamelak, A., Ren, S.G., Bruyette, D., and Melmed, S., “EGFR as a therapeutic target for human,canine, and mouse ACTH-secreting pituitary adenomas”,  J. Clin Invest., 121:4712-21 (2011)

Cooper, O., Vlotides, G., Fukuoka, H., Greene, M.I., and Melmed, S., “Expression and function of ErbB receptors and ligands in the pituitary”, Endocr. Rel Cancer, 2011 18:R197-211 (2011)

Cooper, O., Melmed, S., “Subclinical hyperfunctioning pituitary adenomas: the silent tumors”, Best Pract Res Clin Endocrinol Metab., 26: 447-60 (2012)

Carmichael JD, Fleseriu M: Mifepristone: is there a place in the treatment of Cushing's disease? Endocrine, , 2012

Carmichael JD: Update on the diagnosis and management of hypophysitis. Curr Opin Endocrinol Diabetes Obes, 19(4): 314-21, 2012

Carmichael JD: Lanreotide depot deep subcutaneous injection: a new method of delivery and its associated benefits. Patient Prefer Adherence, 6: 73-82, 2012

Mamelak AN, Carmichael JD, Park P, Bannykh S, Fan X, Bonert HV: Atypical pituitary adenoma with malignant features. Pituitary, 14(1): 92-7, 2011

Carmichael JD, Bonert VS, Mirocha JM, Melmed S: The utility of oral glucose tolerance testing for diagnosis and assessment of treatment outcomes in 166 patients with acromegaly. J. Clin. Endocrinol. Metab., 94(2): 523-7, 2008

Milani D, Carmichael JD, Welkowitz J, Ferris S, Reitz RE, Danoff A, Kleinberg DL: Variability and reliability of single serum IGF-I measurements: impact on determining predictability of risk ratios in disease development. J. Clin. Endocrinol. Metab., 89(5): 2271-4, 2004

Goodarzi MO, Guo X, Cui J, Jones MR, Haritunians T, Xiang AH, Chen YD, Taylor KD, Buchanan TA, Hsueh WA, Raffel LJ, Rotter JI. Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance. Diabetologia. 2013 Mar 14. [Epub ahead of print]

Lee CC, Haffner SM, Wagenknecht LE, Lorenzo C, Norris JM, Bergman RN, Stefanovski D, Anderson AM, Rotter JI, Goodarzi MO, Hanley AJ. Insulin Clearance and the Incidence of Type 2 Diabetes in Hispanics and African Americans: The IRASFamily Study. Diabetes Care. 2013 Apr;36(4):901-7. doi: 10.2337/dc12-1316. Epub2012 Dec 5.

Jones MR, Chazenbalk G, Xu N, Chua AK, Eigler T, Mengesha E, Chen YH, Lee JM, Pall M, Li X, Chen YD, Taylor KD, Mathur R, Krauss RM, Rotter JI, Legro RS, AzzizR, Goodarzi MO. Steroidogenic regulatory factor FOS is underexpressed inpolycystic ovary syndrome (PCOS) adipose tissue and genetically associated withPCOS susceptibility. J Clin Endocrinol Metab. 2012 Sep;97(9):E1750-7. doi:10.1210/jc.2011-2153. Epub 2012 Jun 21.

Guo X, Cui J, Jones MR, Haritunians T, Xiang AH, Chen YD, Taylor KD, Buchanan TA, Davis RC, Hsueh WA, Raffel LJ, Rotter JI, Goodarzi MO. Insulin clearance: confirmation as a highly heritable trait, and genome-wide linkage analysis. Diabetologia. 2012 Aug;55(8):2183-92. doi: 10.1007/s00125-012-2577-2. Epub 2012May 16.

Goodarzi MO, Jones MR, Li X, Chua AK, Garcia OA, Chen YD, Krauss RM, RotterJI, Ankener W, Legro RS, Azziz R, Strauss JF 3rd, Dunaif A, Urbanek M. Replication of association of DENND1A and THADA variants with polycystic ovary syndrome in European cohorts. J Med Genet. 2012 Feb;49(2):90-5. doi:10.1136/jmedgenet-2011-100427. Epub 2011 Dec 17.

Goodarzi MO, Cui J, Chen YD, Hsueh WA, Guo X, Rotter JI. Fasting insulin reflects heterogeneous physiological processes: role of insulin clearance. Am J Physiol Endocrinol Metab. 2011 Aug;301(2):E402-8. doi:10.1152/ajpendo.00013.2011. Epub 2011 May 31.

Mathur R. Insulin Resistance and Obesity: the role of metformin on weight in patients with and without diabetes.  Bariatric Times 8 (1): 2,2011.

Kunkel D, Low K, Lezcano S, Basseri B, Soffer E, Conklin J, Mathur R, Pimentel M. The Efficacy of the glucagon–like peptide 1 analog Exenetide in the treatment of short bowel syndrome.  Neurogastroenterol Motility  Aug 23 (8): 739, 2011.

Basseri RJ, Basseri B, Pimentel M, Chong K, Youdim A, Low K, Hang L, Soffer E, Chang C, Mathur R.  Intestinal methane production in obese humans is associated with higher body mass index. Gastroenterology and Hepatology  8(1): 22-29.2012

Dibaise JK, Frank DN, Mathur R. Impact of the gut microbiota on energy balance: current concepts. American Journal of Gastroenterology  suppl 1:22-27, 2012

Szczepaniak LS, Victor RG, Mathur R, Nelson MD, Szczepaniak EW, Tyer N, Chen I, Unger R, Bergman RN, Lingvay I. Large Racial and Ethnic Variation in Pancreatic Steatosis and its Relationship to Beta Cell Dysfunction in Mild Human Obesity Diabetes Care. 2012 Nov;35(11):2377-83.

Mathur R, Amchai M, Chua KA, Barlow G. Chang C, Mirocha J, Pimentel M. Methane and Hydrogen Positivity on Breath Test is Associated with Greater Body Mass Index and Body Fat.  J Clini Endocrinol Metabol, 2013 April 98(4):E698-702.

Sacks W, Braunstein GD. Papillary Thyroid Cancer. In Thyroid Cancer 9 (1st Edition). Springer Science & Business Media. 2012

Braunstein GD, Sacks W. Thyroid Nodules. In Thyroid Cancer 9 (1st Edition). Springer Science & Business Media. 2012

Waxman A, Sacks W. Radioactive Iodine Therapy for Thyroid Cancer. In Thyroid Cancer 9 (1st Edition). Springer Science & Business Media. 2012

Sacks W, Chang JT, Fung CH, Waxman A, Braunstein GD. "The Effectiveness of Radioactive Iodine for Treatment of Low Risk Thyroid Cancer: A Systematic Analysis of the Peer-Reviewed Literature (January 1966-April 2008)" Thyroid. 2010 20(11);1235-1245.

Yu R, Hui H, and Melmed S (2004) Insulin secretion and action. In Melmed S and Conn PM (eds): Endocrinology. Humana.

Yu R, Nissen NN, Chopra P, Dhall D, Phillips E, Wei M (2009) Diagnosis and treatment of pheochromocytoma in an academic hospital from 1997 to 2007. American Journal of Medicine 122:85-95.

Yu R and Melmed S (2010) Pathogenesis of pituitary tumors. Progress in Brain Research 182:207-227.

Musser N and Yu R (2012) Medullary thyroid carcinoma. In Braunstein G (eds):  Thyroid Cancer. Springer.

Yu R, Nissen NN, Balzer B, Fan X (2012) Novel syndrome of four-limb proximal fragility fractures associated with HIV infection, cholestatic liver failure, and histiocytic infiltration of bone marrow. Hormones 11:204-207.

Yu R, Jih L, Zhai J, Nissen, NN, Colquhoun S, Wolin E, Dhall D (2013) Mixed acinar-endocrine carcinoma of pancreas: new clinical and pathological features in a contemporary series. Pancreas 42:429-435.