Cardiac Autonomic Function in Women with MCD


  • Microvascular coronary dysfunction

Study Name:

Cardiac Autonomic Function in Women with Microvascular Coronary Dysfunction


The purpose of this study is to investigate how the heart reacts to mental stress and to understand more about the cardiac nervous system in women with microvascular coronary dysfunction (MCD). MCD occurs when there are abnormities in small blood vessels/arteries in the heart and symptoms of persistent chest pain.

Participants will be assigned to one of these three groups: chest pain subjects with MCD by abnormal coronary reactivity testing (CRT), chest pain subjects with no MCD, and a normal control group.

Key Inclusion Criteria:

  • Women with symptomatic angina or angina equivalent
  • At least 18 years old
  • No obstructive coronary artery disease at coronary angiography (performed within the previous 24 months)
  • Competent to give informed consent

Key Exclusion Criteria:

  • Obstructive coronary artery disease
  • Acute coronary syndrome
  • Primary valvular heart disease indicating the need for valve repair or replacement
  • Patients with concurrent cardiogenic shock or requiring inotropic or intra-aortic balloon support

Please see additional list of inclusion and exclusion criteria.

Principal Investigator:

Puja Mehta, MD

Co-Investigators Include:

C. Noel Bairey Merz, MD
Daniel Berman, MD
John Friedman, MD

Study Coordinator and Contact:

Completed, Not Enrolling.



IRB No.:


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