Heart Disease of the Small Arteries in Women and Men


  • Coronary microvascular disease

Study Name

Coronary Microvascular Disease and Endothelial Function in Women and Men


The purpose of this study is to understand the mechanisms of heart disease in women and men who have chest pain in the presence of open coronary arteries. Researchers will examine functional abnormalities of the large and small arteries of the heart, as well as assess the effectiveness of using noninvasive tests such as peripheral artery tonometry and cardiac magnetic resonance imaging to aid in diagnosis and detection of abnormalities.

Key Inclusion Criteria

  • Women and men with symptoms of myocardial ischemia and angina or angina equivalent (chest pain, abnormal stress testing, abnormal noninvasive testing)
  • No obstructive coronary artery disease performed within the previous 24 months
  • At least 18 years old
  • Competent to give informed consent

Key Exclusion Criteria

  • Obstructive coronary artery disease greater than or equal to 50 percent luminal diameter stenosis
  • Acute coronary syndrome
  • Primary valvular heart disease clearly indicating the need for valve repair or replacement
  • Patients with concurrent cardiogenic shock or requiring inotropic or intra-aortic balloon support

Please see complete list of inclusion and exclusion criteria.

Principal Investigator

C. Noel Bairey Merz, MD

Co-Investigators Include

Saibal Kar, MD
Raj Makkar, MD
Daniel Berman, MD

Study Coordinator and Contact

Sandy Joung
Phone: 424-315-2365
Email: sandy.joung@cshs.org

Warren Youssefian
Phone: 310-248-6947
Email: warren.youssefian@cshs.org





Date Last Updated