Identification of Adverse Plaque Characteristics by Coronary MRA

Condition

  • Coronary artery disease


Study Name

Identification of Adverse Plaque Characteristics by Coronary Magnetic Resonance Angiography (IRB no. 27850)


Summary

This pilot study focuses on patients who have recently had a coronary computed tomography angiography (CCTA) for suspected coronary artery disease. The purpose of the study is to evaluate whether characteristics of coronary artery plaque can be identified using magnetic resonance imaging.

Investigators will assess whether a research coronary magnetic resonance angiography can identify adverse plaque characteristics (APC’s) observed by CCTA, and whether there is a relationship between APC’s and the presence of coronary artery wall inflammation. Plaque is a buildup of fat, cholesterol, calcium, and other substances found in the blood. Over time, plaque hardens and narrows the coronary arteries.


Eligibility

Key Inclusion Criteria:

  • At least 18 years old
  • Clinically stable individuals with the presence of a non-calcified or mixed plaque AND at least one adverse plaque characteristic present in this plaque by CCTA
  • Able to comprehend and sign informed consent

Key Exclusion Criteria:

  • Greater than 50 percent stenosis of the left main artery or greater than 90 percent stenosis of another proximal coronary segment
  • Coronary artery stent in the segment with the reference plaque
  • Possible pregnancy
  • Any significant arrhythmia (irregular or abnormal heart rhythm)

Please see additional list of inclusion and exclusion criteria.


Principal Investigator

Daniel Berman, MD


Contact

Lisa Miranda-Peats
Phone: 310-423-6753
Email: lisa.mirandapeats@cshs.org