Inclusion and Exclusion Criteria: Heart Disease of the Small Arteries in Women and Men

Inclusion Criteria

  • Women and men with symptoms of myocardial ischemia and angina or angina equivalent (chest pain, abnormal stress testing, abnormal noninvasive testing)
  • No obstructive coronary artery disease performed within the previous 24 months
  • At least 18 years old
  • Competent to give informed consent

Exclusion Criteria

  • Obstructive CAD ≥ 50% luminal diameter stenosis in ≥ 1 epicardial coronary artery
  • Acute coronary syndrome
  • Primary valvular heart disease clearly indicating the need for valve repair or replacement
  • Patients with concurrent cardiogenic shock or requiring inotropic or intra-aortic balloon support
  • Prior or planned percutaneous coronary intervention or CABG or prior acute MI in prior 30 days
  • Prior non-cardiac illness with an estimated life expectancy < 4 years

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