Heart Discoveries at Cedars-Sinai

The Smidt Heart Institute is known around the world for its commitment to translating leading-edge research into routine patient care. Through the years, our innovations and discoveries have improved the prognosis and quality of life for patients battling heart disease.

1924 First electrocardiogram machine installed in Los Angeles.
1952 First use of the thrombolytic enzymes to dissolve blood clots in the heart.
1959 First description of the syndrome of vasopastic angina.
1970 Invention of the Swan-Ganz catheter to measure blood flow and heart pressures.
1973 First use of drugs to dilate blood vessels in heart failure patients, revolutionizing the way severe heart disease is treated.
1981 First use of radioactive isotope Tc-99m to assess blood flow throughout the heart.
1994 First us of the mutant gene-based therapy (apo A-1 Milano) to fight atherosclerosis in experimental animals- a step toward new treatments for coronary artery disease.
1995 Developed imaging software used worldwide for noninvasive quantification of heart function.
2001 First medical center in California and one of the first in the nation to use a portable artificial heart.
2005 First enrolling center in a national trial of percutaneous mitral valve repair.
2006 First comprehensive women's heart center in the United States encompassing clinical care, research and education.
2009 First clinical trial of cardiac-derived stem cells to treat heart attack patients.
2010 National leader in clinical trials of new catheter procedure to replace aortic valves nonsurgically.
2010 First hospital unit in California dedicated solely to treating advanced heart failure patients.