Imaging Research and Clinical Trials

Researchers and clinicians at the S. Mark Taper Foundation Imaging Center perform a range of multidisciplinary studies in neuroradiology, musculoskeletal radiology, nuclear medicine and cardiac imaging. Our researchers investigate improved means to diagnose and treat cancer, aneurysms, spine fractures, neurovascular disease and a range of other conditions and diseases.

Clinical Trials

  • Cook IVC Filter Study
    Principal Investigator: Richard Van Allan, MD
    IRB#: 34301
    Status: Follow Up

    Summary: The objectives of this study are to further evaluate the safety and effectiveness of Cook’s commercially available IVC filters in patients in need of temporary or permanent IVC filter placement for the prevention of pulmonary embolism.

    The Cook Inferior Vena Cava Filter (IVC) Study was initiated by the manufacturer of Cook IVC filters to address FDA concerns about all currently marketed filters. We were invited by Cook Medical, Inc to participate in a study to assess device safety. Cedars-Sinai Medical Center places more filters than any other facility in the nation, with an outstanding record for safety, and we were recently acknowledged as the top-enrolling site for this study. CSMC is routinely sought out for research participation due to the expertise of our Imaging team, in this case, our Interventional Imaging investigators. Patients at risk for blood clots going to their lungs are referred to us for placement of a temporary IVC filter as part of their standard care. We follow patients in the study for symptoms and changes on imaging in assessment of filter safety and efficacy.

  • Proof Of Concept Plus Phase Ii Study Of 99mTc-RhAnnexin V-128 Radionuclide Imaging In Patients With Clinical Suspicion Or Confirmed Diasnosis Of SpondyloarthritiS (sPa)
    Principal Investigator: Alan D. Waxman, M.D.
    IRB#:045359
    Status: Open

    Summary: 99mTc-labelled Annexin has demonstrated the ability to image abnormalities in a variety of diseases with a strong inflammatory component including rheumatoid arthritis, prosthetic joint infection, myocarditis, acute heart transplant rejection. This study aims for early diagnosis and assessment of response to therapy in patients with sPa, compared with MRI which is among the modalities currently used to assess sPa.

  • Resting State Functional Brain MRI (Rsf-MRI) Findings In Chronic Spinal Pain Patients With Longitudinal Follow Up Compared To Normal Controls: Investigator Initiated Pilot Study
    Principal Investigator: M. Marcel Maya, M.D.
    IRB#: 047310
    Status: Open

    Summary: Chronic spinal pain is a major health care issue with major individual and societal costs. Further insight into pain mechanisms will help in developing appropriate management strategies. RSF-MRI offers the promise of noninvasive and objective assessment of neurobiological underpinnings of spinal pain. RSF-MRI also affords means of longitudinal followup and response to various treatment strategies.

    A limited number of participants in the CSMC Pre-Operative Pain Management Program prior to spinal surgery will have three RSf-MRI scans at baseline, following completion of the Pain Management Program and post-operatively to assess the brain in chronic spinal pain patients and determine if finding were reversed following the pain treatment and surgery. An additional limited cohort of healthy volunteers will provide age- and gender- matched normal controls.
  • Functional MRI (FMRI) In Patients With Cerebrospinal Fluid (CSF) Leak Related Headaches
    Principal Investigator: M. Marcel Maya, M.D.
    IRB#: 042446
    Status: Open

    Summary: CSF leak related headaches can be debilitating; using resting functional MRI, this study assesses if there are changes at baseline and post standard of care treatment, if changes are reversible and if they are related and correlate with effect of treatment. This study will facilitate understanding of changes in the brain resting state connectivity in subjects with this condition and will allow investigators to monitor effects of treatment which is sometimes difficult, It could give physicians objective data about treatment response,

  • Locate PET/CT Study In Prostate Cancer (F18-Fluciclovine)
    Principal Investigator: Alan Waxman, MD
    IRB#: 44516
    Status: Completed
  • Evaluation of Hippocampal pH in Patients with Alzheimer’s Disease, Mild Cognitive Impairment and Normal Patients Using Chemical Exchange Saturation Transfer (CEST)
    Principal Investigator: Franklin G. Moser, MD, FACR
    IRB#: 42107
    Status: Completed
  • Near-Infrared Spectroscopy in Disorders of Consciousness: Detecting Neural Activity in the Unresponsive Patient
    Principal Investigator: Franklin G. Moser, MD, FACR
    IRB#: 39341
    Status: Completed
  • A Prospective Study to Screen for and Examination of Lyme Disease using SPECT
    Principal Investigator: Alan Waxman, MD
    IRB#: 38049
    Status: Active

Retrospective Reviews

  • Retrospective Review of Mammograms to Assess the Number of Views Necessary for Optimal Imaging while Reducing Radiation Exposure and Optimizing Efficiency of Throughput
    Principal Investigators: Richard Sukov, M.D./Steven Frankel, M.D.
    IRB#: 051838
    Status: In Development
  • Retrospective Review of the Use of Microwave Ablation in the Treatment of Patients with Both Metastatic Disease to the Lungs and Primary Lung Cancer
    Principal Investigator: Peter Julien, M.D.
    IRB#: 051612
    Status: Open
  • Predicting Meniscal Tear Reparability Using 3 Tesla MRI
    Principal Investigator: Joseph Giaconi, M.D. 3
    IRB#: 050675
    Status: Open
  • Radioactive Seed Localization vs Wire Localization in Biopsy-Proven Breast Cancer: A Retrospective Review
    Principal Investigator: Steven Frankel, MD
    IRB#: 04545
    Status: Open
  • Radioactive Iodine Therapy and the Risk of Leukemia
    Principal Investigator: Alan Waxman, MD
    IRB#: 41664
    Status: Open
  • The Value of the V/Q Scan in the Detection of Airway Disease and Hypoxia
    Principal Investigator: Alan Waxman, MD
    IRB#: 43895
    Status: Open
  • Gastroparesis in Lung Transplant Patients
    Principal Investigator: Alan Waxman, MD
    IRB#: 39590
    Status: Open
  • Imaging in Hepatorenal Patients
    Principal Investigator: Alan Waxman, MD
    IRB#: 29428
    Status: Open
  • Lyme Disease screening using SPECT
    Principal Investigator: Alan Waxman, MD
    IRB#: 36123
    Status: Open
  • A Comparison of Various PET Reading Techniques in the Diagnosis of Dementia
    Principal Investigator: Alan Waxman, MD
    IRB#: 16784
    Status: Open
  • Medical Record Review for MRI Technique Comparison: Linear (Optimark) vs. Macrolytic (Gadovist) Gadolinium-based agents
    Principal Investigator: Franklin Moser, MD, FACR
    IRB#: 42369
    Status: Results Published
  • NeuroQuant to Compare Regional Brain Volumes and FDG-PET: An Investigator Initiated Pilot
    Principal Investigator: Franklin Moser, MD, FACR
    IRB#: 42678
    Status: Open
  • Functional Brain Connectivity and Hippocampal Size Correlation in Patients with Reported Memory Loss
    Principal Investigator: Franklin Moser, MD, FACR
    IRB#: 03782
    Status: Open
  • Imaging for Small Bowel Bacterial Overgrowth
    Principal Investigator: Richard Sukov, MD, FACR
    IRB#: 43654
    Status: Open
  • GI Imaging in Ehlers-Danlos Syndrome--A Retrospective Review with Added Prospective Arm for Comparison
    Principal Investigator: Richard Sukov, MD, FACR
    IRB#: 43653
    Status: Open
  • Imaging Appearance of Sleeve Gastrectomy and its Complications
    Principal Investigator: Richard Sukov, MD, FACR
    IRB#: 36043
    Status: Open

Clinical Procedures Under IRB Oversite For Humanitarian Device Exemption

  • Treatment Protocol of TheraSphere® For Treatment of Unresectable Hepatocellular Carcinoma
    Principal Investigator: Marc L. Friedman, M.D
    IRB#: 22286
    Status: Active

    Disease: Unresectable Hepatocellular (Liver) Cancer
    Summary: Therasphere® is microscopic glass beads embedded with Yttrium-90, a form of high-energy radiation used to treat cancers, in this case, liver cancer that cannot be surgically removed. It is also used as neoadjuvant therapy to shrink the liver tumor before liver surgery or transplant. (An HDE study.)

  • Use of Codman Enterprise Vascular Reconstruction Device (VRD) and Delivery System (DS) in Brain Aneurysms
    Principal Investigator: Franklin G. Moser, MD, FACR
    IRB#: 12671
    Status: Active

    Disease: Brain Aneurysm

    Summary: This device allows the safe placement of metal coils into a brain aneurysm to help close it. A stent--a tubular metallic mesh--is then permanently placed inside the blood vessel to hold the coils in the aneurysm and keep the blood vessel open. (An HDE study.)

  • Use of the Neuroform Stent Systems® for Treatment of Wide Neck, Intracranial, Saccular Aneurysms
    Principal Investigator: Franklin G. Moser, MD, FACR
    IRB#: 04085
    Status: Active

    Disease: Wide Neck Intracranial Saccular Aneurysms

    Summary: The Neuroform 3 Microdelivery Stent System and NeuroformEZ® Stent System are intended to treat patients who have a wide neck intracranial (inside the brain) saccular aneurysm which cannot be treated surgically. (An HDE study.)
  • Wingspan Stent System With Gateway PTA Balloon Catheter
    Principal Investigator: Franklin G. Moser, MD, FACR
    IRB#: 10705
    Status: Active

    Disease: Blockage of Arteries in the Brain

    Summary: The purpose of this is to offer the use of the Wingspan® Stent and Gateway Balloon Catheter device for treatment of patients with neurovascular disease, including recurrent stroke due to blockage of brain vessels which doesn’t respond to medical therapy. (An HDE study.)

 

The S. Mark Taper Foundation Imaging Center provides a full range of advanced imaging, both radiology and cardiology, as well as interventional radiology and interventional tumor (oncology) treatments to the greater Los Angeles area, including Beverly Hills, Encino, Mid-Cities, Sherman Oaks, Silver Lake, Studio City, Toluca Lake and West Hollywood.