• Amyotrophic lateral sclerosis

Study Name:

Accurate Test of Limb Isometric Strength (ATLIS) in ALS


The objective of this study is to assess an investigational strength measurement device called Accurate Test of Limb Isometric Strength (ATLIS) in patients with amyotrophic lateral sclerosis (ALS). ATLIS is designed to evaluate muscle strength and measures the isometric strength of 12 muscle groups in the arms and legs.

Researchers will determine whether ATLIS provides more precise data compared to the use of a questionnaire called ALS-Functional Rating Scale-Revised (ALSFRS-R), which consists of 12 questions about the patient’s ability to function in certain daily activities.

Inclusion Criteria:

  • 18 years or older
  • Diagnosis of clinically possible, laboratory supported probable, probable or clinically definite ALS
  • Capable of providing informed consent and complying with trial procedures
  • Active movement of at least two limbs at the time of study entry
  • Intention to routinely attend clinic for neurological care at the clinical site

Exclusion Criteria:

  • Patients judged by the site clinical investigator to have medical conditions that may limit the ability to safely exert maximal force using the muscles in arms and legs
  • Patients judged by the site clinical investigator to have significant clinical evidence of unstable medical or psychiatric illness

Principal Investigator:

Peggy Allred, PT, DPT


Robert Baloh, MD, PhD
Richard Lewis, MD
Abirami Muthukumaran, MD

Study Coordinator and Contact:

Carolyn Prina
Phone: 310-423-1713



IRB No.:


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