Inclusion and Exclusion Criteria: The Penumbra Liberty Trial

Inclusion Criteria

  • At least 18 years old
  • A saccular intracranial aneurysm with a neck ≥ 4mm or a dome to neck ratio < 2 in the ICA from the cavernous segment to the carotid terminus (including the paraclinoid, ophthalmic, hypophyseal and posterior communicating segments)
  • Life expectancy ≥ 12 months
  • Signed informed consent


Exclusion Criteria

  • Females who are pregnant or intend to become pregnant during the study. (Females of child-bearing potential must have a urinary pregnancy test within 7 days of enrollment).
  • Extradural aneurysms
  • Known multiple untreated cerebral aneurysms at study entry
  • Recent history of subarachnoid hemorrhage, intracranial hemorrhage, or major surgery within one month of enrollment
  • Admission platelet < 50,000 or any known hemorrhagic diathesis, coagulation deficiency, or on oral anticoagulant therapy with an INR > 3.0
  • Contraindication to angiography such as elevated creatinine or known allergy to angiographic contrast
  • Contraindication to CT and/or MRI scans
  • Known allergy to the metal component of the Penumbra Liberty Stent System
  • Evidence of active infection (WBC > 10x109/L)
  • Any medical conditions that will not allow the necessary follow-up for this study (e.g., pre-existing neurological or psychiatric diseases)
  • Current substance abuse/illicit drug use
  • Angiographic evidence of an arterial stenosis proximal to the target lesion that could prevent device deployment
  • Contraindications to study medications (heparin, aspirin, clopidogrel, and radiographic contrasts)


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