The Penumbra Liberty Trial


  • Brain Aneurisms
    • Stenting and coiling

Study Name:

The Penumbra Liberty Trial: Safety and Effectiveness in the Treatment of Wide-Neck Intracranial Aneurysms


Phase 3


The purpose of this study is to test an investigational device, the Penumbra Liberty Stent System, which can be used to help preserve blood flow in a large brain artery when blood flow into an aneurysm is being reduced with metal coils. The Liberty Stent System is made of three components: a stent implant, an introducer sheath and a delivery wire assembly. The purpose of the device is to keep the metal coils inside the aneurysm. The coils are used to fill and alter blood flow into the aneurysm, thereby reducing the volume of blood flow into the aneurysm in order to allow for aneurysm closure.

Key Inclusion Criteria:

  • At least 18 years old
  • A wide-neck brain aneurysm
  • Life expectancy greater than 12 months
  • Signed informed consent

Key Exclusion Criteria:

  • Females who are pregnant or intend to become pregnant during the study
  • Extradural aneurysms
  • Known multiple untreated cerebral aneurysms at study entry
  • Recent history of subarachnoid hemorrhage, intracranial hemorrhage, or major surgery within one month of enrollment

Please see complete list of inclusion and exclusion criteria.

Principal Investigator:

Michael Alexander, MD


Paula Eboli, MD

Study Coordinator and Contact:

Vicki Manoukian
Phone: 310-423-5067



IRB No.:


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