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Cortisone is a type of steroid that is produced naturally by your body in the adrenal gland and it is released from the adrenal gland when your body is under stress. Natural cortisone is released into the blood stream and is relatively short-acting.
Injectable cortisone is synthetically produced and has many different trade names but is a close derivative of your body's own product. The most significant differences are that synthetic cortisone is not injected into the blood stream, but into a particular area of inflammation. Also, the synthetic cortisone is designed to act more potently and for a longer period of time (days instead of minutes).
Since these injections require specific placement in an inflamed area to be of benefit, it is administered directly by an orthopaedic specialist in the office. If there is difficulty locating a proper injection point then your physician may recommend injection under guided ultrasound in the S. Mark Taper Imaging Center.