Role of Gut Factors in Weight and Diabetes Control


Study Name

Longitudinal Pilot Study of Sensory and Metabolic Pathway Alterations Following Gastric Surgery and Caloric Restriction Treatments of Obesity and Diabetes (IRB no. 33124)


This study focuses on patients who have been diagnosed with obesity and Type 2, non-insulin dependent diabetes. The purpose of this study is to compare the effects of three treatments for obesity – gastric bypass surgery, gastric sleeve surgery, and a very low calorie diet on physiologic pathways in order to improve the treatments for these disorders. Researchers will examine how each treatment influences factors such as food preferences, taste, biological markers of obesity and diabetes, and the makeup of microorganisms that live in the digestive tract. Comparing the effects of these methods to achieve weight loss will provide insight into the development of new treatments for diabetes and obesity, as well as knowledge about the prevention of cancer.


Key Inclusion Criteria:
  • 18 to 70 years old
  • Non-smoking
  • Diagnosis of obesity with a body mass index greater than 35
  • Non-insulin-dependent, Type 2 diabetes
Key Exclusion Criteria:
  • Recent cardiovascular event, use of an artificial pacemaker or defibrillator, or other medical or psychiatric condition that would prevent full participation in the study
  • Weight loss of more than 9 kg (19.84 lbs) during the past three months
  • Recent use of weight loss medications or hormone replacement
  • Prior weight loss surgery

Principal Investigator

Stephen Pandol, MD


Emily Rifle
Phone: 310-423-4308