Stem Cell Transplantation

Gordon Wu, MD

The laboratory conducts highly collaborative and innovative research in the field of transplant biology and immunology. Recent projects have focused on blood-vessel induced expression of the insulin gene in embryonic stem cells (collaboration with Don Dafoe, MD), and defining the immunogenic properties of ESC-derived cells in the hepatic lineage (collaboration with Jeff Fair, MD).

Selected Publications

  • Zhu H, Mitsuhashi N, Klein A, Barsky LW, Weinberg K, Barr ML, Demetriou A, Wu GD.  The Role of the Hyaluronan Receptor CD44 in MSC Migration in the Extracellular Matrix. Stem Cells. 2006;24(4):928-935. PMID: 16306150
  • Wu GD, He Y, Chai NN, Toyoda M, Dunn R, Kehry MR, Klein AS, Jordan SC.  Anti-CD20 antibody suppresses anti-HLA antibody formation in a HLA-A2 transgenic mouse model of sensitization. Transpl Immunol.  2008 Jul;19(3-4):178-86.
  • Yao He, Tomohito Sadahiro, Sang-Ik Noh, Hong Wang, Tsuyoshi Todo, Ningning Chai, Andrew S. Klein and Gordon D. Wu. Flow cytometric isolation and phenotypic characterization of two subsets of ED2+ (CD163) hepatic macrophages in rats. Hepatol Res. 2009 Dec;39(12):1208-18. Epub 2009 Jul 13.