Trauma Program Research

Cedars-Sinai (CSMC) has one of the largest state-of-the-art clinical research trial facilities of any private hospital in the nation. The 164,000-square foot research facility is a freestanding building providing space for clinical and basic science research. The facility has a vivarium and operating rooms soley for research purposes. The Burns and Allen Research Institute provides a strong scientific, clinical and administration infrastructure to support these investigations. Core facilities funded by a National Institutes of Health grant provide specialized clinical research trial services. CSMC ranks among the top 10 non-university hospitals nationwide receiving research funding from the National Institutes of Health. Surgical residents are actively involved in trauma research activities. All categorical General Surgery Residents are required to complete at least one year of research and may opt to devote that year to trauma related projects. Others participate on trauma related clinical research throughout their clinical years. Trauma related research is independently done by other specialties such as orthopedic surgery, spine trauma, neurosurgery, cardiac surgery and emergency medicine, with collaboration with the trauma faculty as needed.


Trauma Research Publications


Barmparas G, Cooper Z, Ley EJ, Askari R, Salim A. The effect of cirrhosis on the risk for failure of nonoperative management of blunt liver injuries. Surgery. 2015;158(6):1676-1685. doi:10.1016/j.surg.2015.07.002.

Barmparas G, Lamb AW, Lee D, Nguyen B, Eng J, Bloom MB, Ley EJ. Postoperative infection risk after splenectomy: A prospective cohort study. Int J Surg. 2015;17:10-14. doi:10.1016/j.ijsu.2015.03.007.

Bloom MB, Ley EJ, Liou DZ, Tran T, Chung R, Melo N, Margulies DR. Impact of body mass index on injury in abdominal stab wounds: implications for management. J Surg Res. 2015;197(1):162-166. doi:10.1016/j.jss.2015.03.052. 

Farrell BM, Lin CA, Moon CN. Temporising external fixation of calcaneus fractures prior to definitive plate fixation: a case series. Injury. 2015;46 Suppl 3:S19-22. doi:10.1016/S0020-1383(15)30006-1.

Inaba K, Chouliaras K, Zakaluzny S, Swadron S, Mailhot T, Seif D, Teixeira P, Sivrikoz E, Ives C, Barmparas G, Koronakis N, Demetriades D. FAST ultrasound examination as a predictor of outcomes after resuscitative thoracotomy: a prospective evaluation. Ann Surg. 2015;262(3):512-518; discussion 516-518. doi:10.1097/SLA.0000000000001421.

Ko A, Zaw AA, Barmparas G, Hoang DM, Murry JS, Li T, Ashrafian S, McNeil NJ, Margulies DR, Ley EJ. Abdominal Injuries in the “Found Down”: Is Imaging Indicated? J Am Coll Surg. 2015;221(1):17-24. doi:10.1016/j.jamcollsurg.2015.03.025.

Lapchak PA, Boitano PD, Butte PV, Fisher DJ, Hölscher T, Ley EJ, Nuño M, Voie AH, Rajput PS. Transcranial Near-Infrared Laser Transmission (NILT) Profiles (800 nm): Systematic Comparison in Four Common Research Species. PLoS ONE.  2015;10(6):e0127580. doi:10.1371/journal.pone.0127580.

Lee DH, Barmparas G, Fierro N, Sun BJ, Ashrafian S, Li T, Ley EJ. Splenectomy is associated with a higher risk for venous thromboembolism: A prospective cohort study. Int J Surg. 2015;24(Pt A):27-32. doi:10.1016/j.ijsu.2015.10.011.

Liou DZ, Barmparas G, Zaw A, Bukur M, Salim A, Ley EJ. Alcohol intoxication may be associated with reduced truncal injuries after blunt trauma. Am J Surg. 2015;210(1):87-92. doi:10.1016/j.amjsurg.2014.11.015. 

Murry JS, Hoang DM, Ashragian S, Liou DZ, Barmparas G, Chung R, Alban RF, Margulies DR, Ley EJ. Selective Nonoperative Management of Abdominal Stab Wounds. Am Surg. 2015;81(10):1034-1038.

Murry JS, Zaw AA, Hoang DM, Mehrzadi D, Tran D, Nuno M, Bloom M, Melo N, Margulies DR, Ley EJ. Activation of Massive Transfusion for Elderly Trauma Patients. Am Surg. 2015;81(10):945-949.

Painter TJ, Rickerds J, Alban RF. Immune enhancing nutrition in traumatic brain injury - A preliminary study. Int J Surg. 2015;21:70-74. doi:10.1016/j.ijsu.2015.07.008.

Thomsen GM, Vit J-P, Lamb A, Gowing G, Shelest O, Alkaslasi M, Ley EJ, Svendsen CN. Acute Traumatic Brain Injury Does Not Exacerbate Amyotrophic Lateral Sclerosis in the SOD1 (G93A) Rat Model. eNeuro. 2015;2(3). doi:10.1523/ENEURO.0059-14.2015.

Zaw AA, Murry J, Hoang D, Chen K, Louy C, Bloom MB, Melo N, Alban RF, Margulies DR, Ley EJ. Epidural Analgesia after Rib Fractures. Am Surg. 2015;81(10):950-954.

Zaw AA, Stewart D, Murry JS, Hoang DM, Sun B, Ashrafian S, Hotz H, Chung R, Margulies DR, Ley EJ. CT Chest with IV Contrast Compared with CT Angiography after Blunt Trauma. Am Surg. 2015;81(10):1080-1083.

Alban RF, Gibbons BL, Bershad VL. Improving Donor Conversion Rates at a Level One Trauma Center: Impact of Best Practice Guidelines. Cureus. 2016;8(11):e891. doi:10.7759/cureus.891.

Barmparas G, Cooper Z, Haider AH, Havens JM, Askari R, Salim A. The elderly patient with spinal injury: treat or transfer? J Surg Res. 2016;202(1):58-65. doi:10.1016/j.jss.2015.12.032.

Barmparas G, Ko A, Harada MY, Zaw AA, Murry JS, Smith EJT, Ashrafian S, Sun BJ, Ley EJ. Decreasing maintenance fluids in normotensive trauma patients may reduce intensive care unit stay and ventilator days. J Crit Care. 2016;31(1):201-205. doi:10.1016/j.jcrc.2015.09.030.

Barmparas G, Martin MJ, Wiegmann DA, Catchpole KR, Gewertz BL, Ley EJ. Increased Age Predicts Failure to Rescue. Am Surg. 2016;82(11):1073-1079.

Bloom MB, Serna-Gallegos D, Ault M, Khan A, Chung R, Ley EJ, Melo N, Margulies DR. Effect of Thoracentesis on Intubated Patients with Acute Lung Injury. Am Surg. 2016;82(3):266-270.

Bloom MB, Zaw AA, Hoang DM, Mason R, Alban RF, Chung R, Melo N, Volod O, Ley EJ, Margulies DR. Body mass index strongly impacts the diagnosis and incidence of heparin-induced thrombocytopenia in the surgical intensive care unit. J Trauma Acute Care Surg. 2016;80(3):398-403; discussion 403-404. doi:10.1097/TA.0000000000000952.

Butler KL, Chang Y, DeMoya M, Feinstein A, Ferrada P, Maduekwe U, Maung AA, Melo N, Odom S, Olasky J, Reinhorn M, Smink DB, Stassen N, Wilson CT, Fagenholz P, Kaafarani H, King D, Yeh DD, Velmahos G, Stefanidis D. Needs assessment for a focused radiology curriculum in surgical residency: a multicenter study. Am J Surg. 2016;211(1):279-287. doi:10.1016/j.amjsurg.2015.05.027.

Chou D, Harada MY, Barmparas G, Ko A, Ley EJ, Margulies DR, Alban RF. Field intubation in civilian patients with hemorrhagic shock is associated with higher mortality. J Trauma Acute Care Surg. 2016;80(2):278-282. doi:10.1097/TA.0000000000000901.

Giancarelli A, Birrer KL, Alban RF, Hobbs BP, Liu-DeRyke X. Hypocalcemia in trauma patients receiving massive transfusion. J Surg Res. 2016;202(1):182-187. doi:10.1016/j.jss.2015.12.036.

Ko A, Harada MY, Barmparas G, Chung K, Mason R, Yim DA, Dhillon N, Margulies DR, Gewertz BL, Ley EJ. Association Between Enoxaparin Dosage Adjusted by Anti-Factor Xa Trough Level and Clinically Evident Venous Thromboembolism After Trauma. JAMA Surg. 2016;151(11):1006-1013. doi:10.1001/jamasurg.2016.1662.

Ko A, Harada MY, Barmparas G, Thomsen GM, Alban RF, Bloom MB, Chung R, Melo N, Margulies DR, Ley EJ. Early propranolol after traumatic brain injury is associated with lower mortality. J Trauma Acute Care Surg. 2016;80(4):637-642. doi:10.1097/TA.0000000000000959.

Ko A, Harada MY, Barmparas G, Jay J, Sun BJ, Chen E, Mehrzadi D, Patel B, Mason R, Ley EJ. Reducing acute kidney injury due to vancomycin in trauma patients. J Trauma Acute Care Surg. 2016;81(2):352-357. doi:10.1097/TA.0000000000001105.

Ko A, Harada MY, Murry JS, Nuño M, Barmparas G, Ma AA, Thomsen GM, Ley EJ. Heart rate in pediatric trauma: rethink your strategy. J Surg Res. 2016;201(2):334-339. doi:10.1016/j.jss.2015.11.011.

Ko A, Harada MY, Smith EJT, Scheipe M, Alban RF, Melo N, Margulies DR, Ley EJ. Pain Assessment and Control in the Injured Elderly. Am Surg. 2016;82(10):867-871.

Ko A, Murry JS, Hoang DM, Harada MY, Aquino L, Coffey C, Sax HC, Alban RF. High-value care in the surgical intensive care unit: effect on ancillary resources. J Surg Res. 2016;202(2):455-460. doi:10.1016/j.jss.2016.01.040.

Lin CA, Swiontkowski M, Bhandari M, Walter SD, Schemitsch EH, Sanders D, Tornetta P. Reaming Does Not Affect Functional Outcomes After Open and Closed Tibial Shaft Fractures: The Results of a Randomized Controlled Trial. J Orthop Trauma. 2016;30(3):142-148. doi:10.1097/BOT.0000000000000497.

Lin CA, Bhandari M, Guyatt G, Walter SD, Schemitsch EH, Swiontkowski M, Sanders D, Tornetta P, SPRINT Investigators. Does Participation in a Randomized Clinical Trial Change Outcomes? An Evaluation of Patients Not Enrolled in the SPRINT Trial. J Orthop Trauma. 2016;30(3):156-161.

Liou DZ, Singer MB, Barmparas G, Harada MY, Mirocha J, Bukur M, Salim A, Ley EJ. Insulin-dependent diabetes and serious trauma. Eur J Trauma Emerg Surg. 2016;42(4):491-496. doi:10.1007/s00068-015-0561-5.

Liou DZ, Barmparas G, Harada M, Chung R, Melo N, Ley EJ, Salim A, Bukur M. Work Hour Reduction: Still Room for Improvement. J Surg Educ. 2016;73(1):173-179. doi:10.1016/j.jsurg.2015.07.016.

Liou DZ, Ko A, Volod O, Barmparas G, Harada MY, Martin MJ, Salim A, Dhillon N, Thomsen GM, Ley EJ. Thromboelastography After Murine TBI and Implications of Beta-Adrenergic Receptor Knockout. Neurocrit Care. 2016;25(1):145-152. doi:10.1007/s12028-015-0223-9.

McLafferty FS, Barmparas G, Ortega A, Roberts P, Ko A, Harada M, Nuño M, Black KL, Ley EJ. Predictors of improved functional outcome following inpatient rehabilitation for patients with traumatic brain injury. NeuroRehabilitation. 2016;39(3):423-430. doi:10.3233/NRE-161373.

Murry JS, Hoang DM, Barmparas G, Harada MY, Bukur M, Bloom MB, Inaba K, Margulies DR, Salim A, Ley EJ. Prospective evaluation of early propranolol after traumatic brain injury. J Surg Res. 2016;200(1):221-226. doi:10.1016/j.jss.2015.06.045.

Rajaee SS, Lin CA, Moon CN. Primary total elbow arthroplasty for distal humeral fractures in elderly patients: a nationwide analysis. J Shoulder Elbow Surg. 2016;25(11):1854-1860. doi:10.1016/j.jse.2016.05.030.

Thomsen GM, Ma AM, Ko A, Harada MY, Wyss L, Haro PS, Vit J-P, Shelest O, Rhee P, Svendsen CN, Ley EJ. A model of recurrent concussion that leads to long-term motor deficits, CTE-like tauopathy and exacerbation of an ALS phenotype. J Trauma Acute Care)Surg. 2016;81(6):1070-1079. doi:10.1097/TA.0000000000001248.

Zaw AA, Stewart D, Murry JS, Hoang DM, Sun B, Ashrafian S, Hotz H, Chung R, Margulies DR, Ley EJ. CT Chest with IV Contrast Compared with CT Angiography after Blunt Trauma. Am Surg. 2016;82(1):41-45.

Ahl R, Barmparas G, Riddez L, Ley EJ, Wallin G, Ljungqvist O, Mohseni S. Does Beta-Blockade Reduce the Risk of Depression in Patients with Isolated Severe Extracranial Injuries? World J Surg. 2017;41(7):1801-1806. doi:10.1007/s00268-017-3935-5.

Barmparas G, Ley EJ, Martin MJ, Ko A, Harada M, Weigmann D, Catchpole KR, Gewertz BL. Failure to rescue the elderly: a superior quality metric for trauma centers. Eur J Trauma Emerg Surg. March 2017. doi:10.1007/s00068-017-0782-x.

Barmparas G, Dhillon NK, Smith EJT, Tatum JM, Chung R, Melo N, Ley EJ, Margulies DR. Assault in children admitted to trauma centers: Injury patterns and outcomes from a 5-year review of the national trauma data bank. Int J Surg. 2017;43:137-144. doi:10.1016/j.ijsu.2017.05.068.

Barmparas G, Ko A, Dhillon NK, Tatum JM, Choi M, Ley EJ, Margulies DR. Extreme Interventions for Trauma Patients in Extremis: Variations among Trauma Centers. Am Surg. 2017;83(10):1033-1039.

Bez M, Sheyn D, Tawackoli W, Avalos P, Shapiro G, Giaconi JC, Da X, David SB, Gavrity J, Awad HA, Bae HW, Ley EJ, Kremen TJ, Gazit Z, Ferrara KW, Pelled G, Gazit D. In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs. Sci Transl Med. 2017;9(390). doi:10.1126/scitranslmed.aal3128.

Bloom MB, Lu J, Tran T, Bukur M, Chung R, Ley EJ, Melo N, Salim A, Margulies DR. Direct Two-Minute Unassisted Breathing Evaluation (DTUBE) Is an Attractive Alternative to Longer Spontaneous Breathing Trials: A Prospective Observational Study. Am Surg. 2017;83(3):308-313.

Cohn Yakubovich D, Sheyn D, Bez M, Schary Y, Yalon E, Sirhan A, Amira M, Yaya A, De Mel S, Da X, Ben-David S, Tawackoli W, Ley EJ, Gazit D, Gazit Z, Pelled G. Systemic administration of mesenchymal stem cells combined with parathyroid hormone therapy synergistically regenerates multiple rib fractures. Stem Cell Res Ther. 2017;8(1):51. doi:10.1186/s13287-017-0502-9. 

Dhillon NK, Ko A, Smith EJT, Kharabi M, Castongia J, Nurok M, Gewertz BL, Ley EJ. Potentially Avoidable Surgical Intensive Care Unit Admissions and Disposition Delays. JAMA Surg. 2017;152(11):1015-1022. doi:10.1001/jamasurg.2017.2165.

Dhillon NK, Smith EJT, Ko A, Harada MY, Polevoi D, Liang R, Barmparas G, Ley EJ. Extubation to high-flow nasal cannula in critically ill surgical patients. J Surg Res. 2017;217:258-264. doi:10.1016/j.jss.2017.06.026.

Eaton KP, Levy K, Soong C, Pahwa AK, Petrilli C, Ziemba JB, Cho HJ, Alban R, Blanck JF, Parsons AS. Evidence-Based Guidelines to Eliminate Repetitive Laboratory Testing. JAMA Intern Med. 2017;177(12):1833-1839. doi:10.1001/jamainternmed.2017.5152.

Harada MY, Hoang DM, Zaw AA, Murry JS, Volod O, Sun BJ, Nuño M, Mason R, Margulies DR, Ley EJ. Overtreatment of Heparin-Induced Thrombocytopenia in the Surgical ICU. Crit Care Med. 2017;45(1):28-34. doi:10.1097/CCM.0000000000002002.

Harada MY, Ko A, Barmparas G, Smith EJT, Patel BK, Dhillon NK, Thomsen GM, Ley EJ. 10-Year trend in crystalloid resuscitation: Reduced volume and lower mortality. Int J Surg. 2017;38:78-82. doi:10.1016/j.ijsu.2016.12.073.

Ju DG, Rajaee SS, Mirocha J, Lin CA, Moon CN. Nationwide Analysis of Femoral Neck Fractures in Elderly Patients: A Receding Tide. J Bone Joint Surg Am. 2017;99(22):1932-1940. doi:10.2106/JBJS.16.01247.

Ko A, Harada MY, Dhillon NK, Patel KA, Kirillova LR, Kolus RC, Torbati S, Ley EJ. Decreased transport time to the surgical intensive care unit. Int J Surg. 2017;42:54-57. doi:10.1016/j.ijsu.2017.04.030.

Kobayashi L, Barmparas G, Bosarge P, Brown CV, Bukur M, Carrick MM, Catalano RD, Holly-Nicolas J, Inaba K, Kaminski S, Klein AL, Kopelman T, Ley EJ, Martinez EM, Moore FO, Murry J, Nirula R, Paul D, Quick J, Rivera O, Schreiber M, Coimbra R, AAST Multicenter Prospective Observational Study of Trauma Patients on Novel Oral Anticoagulants Study Group. Novel oral anticoagulants and trauma: The results of a prospective American Association for the Surgery of Trauma Multi-Institutional Trial. J Trauma Acute Care Surg. 2017;82(5):827-835. doi:10.1097/TA.0000000000001414.

Martin MJ, Bush LD, Inaba K, Byerly S, Schreiber M, Peck KA, Barmparas G, Menaker J, Hazelton JP, Coimbra R, Zielinski MD, Brown CVR, Ball CG, Cherry-Bukowiec JR, Burlew CC, Dunn J, Minshall CT, Carrick MM, Berg GM, Demetriades D, Long W, WTA C-Spine Study Group. Cervical spine evaluation and clearance in the intoxicated patient: A prospective Western Trauma Association Multi-Institutional Trial and Survey. J Trauma Acute Care Surg. 2017;83(6):1032-1040. doi:10.1097/TA.0000000000001650.

Nurok M, Warsh J, Griner T, Kharabi M, Castongia J, Overbeck C, Krueger L, Coleman B, Ramzy D, Chung J, Chan A, Ley E, Kubendran S, Parrish N, Yu Z, Langberg M, Finder S, Rosen BT, Kaplan RS, Sax H, Arabia F. Extracorporeal Membrane Oxygenation Appropriateness: An Interdisciplinary Consensus-Based Approach. Anesth Analg. December 2017. doi:10.1213/ANE.0000000000002723.

Rajaee SS, Yalamanchili D, Noori N, Debbi E, Mirocha J, Lin CA, Moon CN. Increasing Use of Reverse Total Shoulder Arthroplasty for Proximal Humerus Fractures in Elderly Patients. Orthopedics. 2017;40(6):e982-e989. doi:10.3928/01477447-20170925-01.

Tatum JM, Barmparas G, Ko A, Dhillon N, Smith E, Margulies DR, Ley EJ. Analysis of Survival After Initiation of Continuous Renal Replacement Therapy in a Surgical Intensive Care Unit. JAMA Surg. 2017;152(10):938-943. doi:10.1001/jamasurg.2017.1673.

Tatum JM, Dhillon NK, Ko A, Smith EJT, Melo N, Barmparas G, Ley EJ. Refusal of cervical spine immobilization after blunt trauma: Implications for initial evaluation and management: A retrospective cohort study. Int J Surg. 2017;48:228-231. doi:10.1016/j.ijsu.2017.11.027.

Tatum JM, Melo N, Ko A, Dhillon NK, Smith EJT, Yim DA, Barmparas G, Ley EJ. Validation of a field spinal motion restriction protocol in a level I trauma center. J Surg Res. 2017;211:223-227. doi:10.1016/j.jss.2016.12.030.

Tatum JM, White T, Kang C, Ley EJ, Melo N, Bloom M, Alban RF. Prospective Trial of House Staff Time to Response and Intervention in a Surgical Intensive Care Unit: Pager vs. Smartphone. J Surg Educ. 2017;74(5):851-856. doi:10.1016/j.jsurg.2017.03.003.

Thomsen GM, Ko A, Harada MY, Ma A, Wyss L, Haro P, Vit J-P, Avalos P, Dhillon NK, Cho N, Shelest O, Ley EJ. Clinical correlates to assist with chronic traumatic encephalopathy diagnosis: Insights from a novel rodent repeat concussion model. J Trauma Acute Care Surg. 2017;82(6):1039-1048. doi:10.1097/TA.0000000000001443.

Alban RF, Nuño M, Ko A, Barmparas G, Lewis AV, Margulies DR. Weaker gun state laws are associated with higher rates of suicide secondary to firearms. J Surg Res. 2018;221:135-142. doi:10.1016/j.jss.2017.08.027.

Barmparas G, Dhillon NK, Smith EJ, Mason R, Melo N, Thomsen GM, Margulies DR, Ley EJ. Patterns of vasopressor utilization during the resuscitation of massively transfused trauma patients. Injury. 2018;49(1):8-14. doi:10.1016/j.injury.2017.09.021.

Barmparas G, Harada MY, Ko A, Dhillon NK, Smith EJT, Li T, Mohseni S, Ley EJ. The Effect of Early Positive Cultures on Mortality in Ventilated Trauma Patients. Surg Infect (Larchmt). April 2018. doi:10.1089/sur.2017.268.

Barmparas G, Patel DC, Linaval NT, Dhillon NK, Patel KA, Margulies DR, Ley EJ. A Negative CT May Be Sufficient to Safely Discharge Patients with Abdominal Seatbelt Sign from The Emergency Department: A Case Series Analysis. J Trauma Acute Care Surg. March 2018. doi:10.1097/TA.0000000000001872.

Dhillon NK, Barmparas G, Thomsen GM, Patel KA, Linaval NT, Gillette E, Margulies DR, Ley EJ. Nonoperative Management of Blunt Splenic Trauma in Patients with Traumatic Brain Injury: Feasibility and Outcomes. World J Surg. January 2018. doi:10.1007/s00268-018-4494-0.

Dhillon NK, Smith EJT, Gillette E, Mason R, Barmparas G, Gewertz BL, Ley EJ. Trauma patients with lower extremity and pelvic fractures: Should anti-factor Xa trough level guide prophylactic enoxaparin dose? Int J Surg. 2018;51:128-132. doi:10.1016/j.ijsu.2018.01.023.

Dhillon NK, Smith EJT, Ko A, Harada MY, Yang AR, Patel KA, Barmparas G, Ley EJ. The risk factors of venous thromboembolism in massively transfused patients. J Surg Res. 2018;222:115-121. doi:10.1016/j.jss.2017.09.038.

Dhillon NK, Tseng J, Barmparas G, Harada MY, Ko A, Smith EJT, Thomsen GM, Ley EJ. Impact of early positive cultures in the elderly with traumatic brain injury. J Surg Res. 2018;224:140-145. doi:10.1016/j.jss.2017.11.031.

Ley EJ, Leonard SD, Barmparas G, Dhillon NK, Inaba K, Salim A, OʼBosky KR, Tatum D, Azmi H, Ball CG, Engels PT, Dunn JA, Carrick MM, Meizoso JP, Lombardo S, Cotton BA, Schroeppel TJ, Rizoli S, Chang DSJ, de León LA, Rezende-Neto J, Jacome T, Xiao J, Mallory G, Rao K, Widdel L, Godin S, Coates A, Benedict LA, Nirula R, Kaul S, Li T, Beta Blockers TBI Study Group Collaborators. Beta blockers in critically ill patients with traumatic brain injury: Results from a multicenter, prospective, observational American Association for the Surgery of Trauma study. J Trauma Acute Care Surg. 2018;84(2):234-244. doi:10.1097/TA.0000000000001747