Previous Research: Discovering Genes for Diabetes and Obesity

Palmer ND*, Goodarzi MO*, Langefeld CD*, Wang N*, Guo X, Taylor KD, Fingerlin TE, Norris JM, Buchanan TA, Xiang AH, et al. Genetic variants associated with quantitative glucose homeostasis traits translate to Type 2 diabetes in Mexican Americans: the GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium. Diabetes. 2015;64(5):1853-1866. *Equal first author status.

Knowles JW, Xie W, Zhang Z, Chennemsetty I, Assimes TL, Paananen J, Hansson O, Pankow J, Goodarzi MO, Carcamo-Orive I, et al. Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. J Clin Invest. 2015;125(4):1739-1751.

Wessel J, Chu AY, Willems SM, Wang S, Yaghootkar H, Brody JA, Dauriz M, Hivert M-F, Raghavan S, et al., Goodarzi MO. Low-frequency and rare exome chip variants associate with fasting glucose and Type 2 diabetes susceptibility. Nat Commun. 2015 Jan 29;6:5897.

Meta-analysis of Type 2 diabetes in African Americans (MEDIA) Consortium including Goodarzi MO. Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of Type 2 diabetes. PLOS Genet. 2014;10(8):e1004517.

Chen P*, Takeuchi F*, Lee JY*, Li H*, Wu JY*, Liang J*, Long J*, Tabara Y*, Goodarzi MO*, et al. Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians. Diabetes. 2014;63(7):2551-2562. *Equal first author status.

Luan B, Goodarzi MO, Phillips NG, Guo X, Chen YDI, Yao J, Allison M, Rotter JI, Shaw R, Montminy M. Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4. Cell Metab. 2014;19(6):1058-1065.

Goodarzi MO, Langefeld CD, Xiang AH, Chen YD, Guo X, Hanley AJ, Raffel LJ, Kandeel F, Nadler JL, Buchanan TA, et al. Insulin sensitivity and insulin clearance are heritable and have strong genetic correlation in Mexican Americans. Obesity (Silver Spring). 2014;22(4):1157-1164.;jsessionid=9B7267BAB9029CD6738391B31D0ADCF1.f02t01.

Kuo JZ, Sheu WH, Assimes TL, Hung YJ, Absher D, Chiu YF, Mak J, Wang JS, Kwon S, Hsu CC, Goodarzi MO, et al. Trans-ethnic fine mapping identifies a novel independent locus at the 3' end of CDKAL1 and novel variants of several susceptibility loci for Type 2 diabetes in a Han Chinese population. Diabetologia. 2013;56(12):2619-2628.

Goodarzi MO, Li X, Krauss RM, Rotter JI, Chen YD. Relationship of sex to diabetes risk in statin trials. Diabetes Care. 2013;36(7):e100-101.

Goodarzi MO, Guo X, Cui J, Jones MR, Haritunians T, Xiang AH, Chen YDI, Taylor KD, Buchanan TA, Hsueh WA, Raffel LJ, Rotter JI. Systematic evaluation of validated Type 2 diabetes and glycemic trait loci for association with insulin clearance. Diabetologia. 2013;56(6):1282-1290.

Lee CC, Haffner SM, Wagenknecht LE, Lorenzo C, Norris JM, Bergman RN, Stefanovski D, Anderson AM, Rotter JI, Goodarzi MO, Hanley AJ. Insulin clearance and the incidence of Type 2 diabetes in Hispanics and African Americans: the IRAS Family Study. Diabetes Care. 2013;36(4):901-907.

Guo X, Cui J, Jones MR, Haritunians T, Xiang AH, Chen YDI, Taylor KD, Buchanan TA, Davis RC, Hsueh WA, Raffel LJ, Rotter JI, Goodarzi MO. Insulin clearance: confirmation as a highly heritable trait, and genome-wide linkage analysis. Diabetologia. 2012;55(8):2183-2192.

Goodarzi MO, Cui J, Chen YD, Hsueh WA, Guo X, Rotter JI. Fasting insulin reflects heterogeneous physiological processes: role of insulin clearance. Am J Physiol Endocrinol Metab. 2011;301(2):E402-408.

Rich SS*, Goodarzi MO*, Palmer ND, Langefeld CD, Ziegler J, Haffner SM, Bryer-Ash M, Norris JM, Taylor KD, Haritunians T, et al. A genome-wide association scan for acute insulin response to glucose in Hispanic Americans: the IRAS Family Study. Diabetologia. 2009;52:1326-33. *Equal first author status.

Goodarzi MO, Psaty BM. Glucose lowering to control macrovascular disease in Type 2 diabetes: treating the wrong surrogate end point? JAMA. 2008;300(17):2051-2053.

Goodarzi MO, Lehman DM, Taylor KD, Guo X, Cui J, Quiñones MJ, Clee SM, Yandell BS, Blangero J, Hsueh WA, et al. SORCS1: a novel human Type 2 diabetes susceptibility gene suggested by the mouse. Diabetes. 2007;56(7):1922-1929.

Goodarzi MO, Taylor KD, Guo X, Hokanson JE, Haffner SM, Sui J, Chen YD, Wagenknecht LE, Bergman RN, Rotter JI. Haplotypes in the lipoprotein lipase gene influence fasting insulin and discovery of a new risk haplotype. J Clin Endocrinol Metab. 2007;92(1):293-296.

Goodarzi MO, Bryer-Ash M. Metformin revisited: re-evaluation of its properties and role in the pharmacopoeia of modern antidiabetic agents. Diabetes Obes Metab. 2005;7(6):654-665.

Goodarzi MO, Taylor KD, Guo X, Quiñones MJ, Cui J, Li Y, Saad MF, Yang H, Hsueh WA, Hodis HN, Rotter JI. Association of the diabetes gene calpain-10 with subclinical atherosclerosis: the Mexican-American Coronary Artery Disease Study. Diabetes. 2005;54(4):1228-1232.

Goodarzi MO, Taylor KD, Guo X, Quiñones MJ, Cui J, Li X, Hang T, Yang H, Holmes E, Hsueh WA, et al. Variation in the gene for muscle-specific AMP deaminase is associated with insulin clearance, a highly heritable trait. Diabetes. 2005;54(4):1222-1227.

Goodarzi MO, Guo X, Taylor KD, Quiñones MJ, Saad MF, Yang H, Hsueh WA, Rotter JI. Lipoprotein lipase is a gene for insulin resistance in Mexican Americans. Diabetes. 2004;53(1):214-220.

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