Previous Research: Sex-Based Differences Regarding Obesity and Diabetes

Morselli E, Fuente-Martin E, Finan B, Kim M, Frank A, Garcia-Caceres C, Navas CR, Gordillo R, Neinast M, Kalainayakan SP, Li DL, Gao Y, Yi CX, Hahner L, Palmer BF, Tschöp MH, Clegg DJ. Hypothalamic PGC-1α protects against high-fat diet exposure by regulating ERα. Cell Rep. 2014 October;9(2):633-645.

Lapid K, Lim A, Clegg DJ, Zeve D, Graff JM. Oestrogen signaling in white adipose progenitor cells inhibits differentiation into brown adipose and smooth muscle cells. Nat Commun. 2014 Oct 21;5:5196.

Kim M, Neinast MD, Frank AP, Sun K, Park J, Zehr JA, Vishvanath L, Morselli E, Amelotte M, Palmer BF, Gupta RK, Scherer PE, Clegg DJ. ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue. Mol Metab. 2014 Sept;3(6):642-651.

Cao X, Xu P, Oyola MG, Xia Y, Yan X, Saito K, Zou F, Wang C, Yang Y, Hinton A Jr, Yan C, Ding H, Zhu L, Yu L, Yang B, Feng Y, Clegg DJ, et al. Estrogens stimulate serotonin neurons to inhibit binge-like eating in mice. J Clin Invest. 2014 Oct 1;124(10):4351-4362.

Palmer BF, Clegg DJ. Oxygen sensing and metabolic homeostasis. Mol Cell Endocrinol. 2014 Nov;397(1-2):51-58.

Park J, Morley TS, Kim M, Clegg DJ, Scherer PE. Obesity and cancer: mechanisms underlying tumor progression and recurrence. Nat Rev Endocrinol. 2014 Aug;10(8):455-465.

Frank A, Brown LM, Clegg DJ. The role of hypothalamic estrogen receptors in metabolic regulation. Front Neuroendocrinol. 2014 May 29;35(4):550-557. pii: S0091-3022(14)00049-1.

Davis KE, Carstens EJ, Irani BG, Gent LM, Hahner LM, Clegg DJ. Sexually dimorphic role of G protein-coupled estrogen receptor (GPER) in modulating energy homeostasis. Horm Behav. 2014 Jun;66(1):196-207.

Clegg DJ, Palmer BF. Effects of an estrogen receptor α variant. N Engl J Med. 2013 Oct 24;369(17):1663-1664.

Davis KE, Neinast MD, Sun K, Skiles WM, Bills JD, Zehr AJ, Zeve D, Hahner LD, Cox DW, Gent LM, Xu Y, Wand ZV, Khan SA, Clegg DJ. The sexually dimorphic role of adipose and adipocyte estrogen receptors in modulating adipose tissue expansion, inflammation and fibrosis. Mol Metab. 2013 Aug;2(3):227-242.

Clegg DJ. Minireview: the year in review of estrogen regulation of metabolism. Mol Endocrinol. 2012 Dec;26(12):1957-1960.

Clegg DJ, Gotoh K, Kemp C, Wortman MD, Benoit SC, Brown LM, Brown LM, D’Alessio D, Tso P, Seeley RJ, Woods SC. Consumption of a high-fat diet induces central insulin resistance independent of adiposity. Physiol Behav. 2011 Apr 18;103(1):10-16.

Clegg DJ, Brown LM, Zigman JM, Kemp CJ, Strader AD, Benoit SC, Woods SC, Mangiaracina M, Geary N. Estradiol-dependent decrease in the orexigenic potency of ghrelin in female rats. Diabetes. 2007 Apr;56(4):1051-1058.

Clegg DJ, Heffelfinger SC. Obesity: its influence on breast cancer susceptibility. Womens Health (London). 2006 Jul;2(4):577-585.

Clegg DJ, Brown LM, Woods SC, Benoit SC. Gonadal hormones determine sensitivity to central leptin and insulin. Diabetes. 2006 Apr;55(4):978-987.

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