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Masayuki Fukata, MD, PhD
Research Scientist, Gastroenterology
Research Scientist, Immunology Research
|Assistant Clinical Professor, Medicine|
Awards and Activities
|The Wisdom Family Research Scholar Award.||2011|
|Award for young investigator in Japan Society of Histochemistry and Cytochemistry.||2002|
|Ad hoc Reviewer: Broad Medical Research Program||2012 - 2014|
|Ad hoc Reviewer: Health Research Board (HRB), Health Research Awards, Ireland||2011|
|Ad hoc Reviewer: National Institute of Health, NIDDK/NIAID, GMPB, special emphasis panels||Current|
|Ad hoc Reviewer: Medical Research Council (Lond, UK)||2009 - 2011|
|Member: American Gastroenterological Association||2010|
Our research focus includes the role of innate immunity and their interaction with commensal and/or pathogenic microbes in mucosal homeostasis and disease pathogenesis. The laboratory studies the innate regulation and induction of protective immunity during reinfection and chronic inflammation in the intestine. Expectantly, a better understanding of intestinal immune regulation especially in the context of host-microbial interactions will lead to the development of effective therapies to treat and/or prevent many inflammatory and infectious diseases mainly in but not limited to intestinal mucosa.
We have made significant contributions to the scientific field of intestinal mucosal immunity and inflammation. These include the discovery of TRIF-mediated host defense mechanism against Gram-negative pathogens. We described TRIF-dependent innate response to commensal bacteria as an important regulator of Th17 cell differentiation and plasticity in the intestine. We also demonstrated an important regulation of IL-10 expression by human intestinal epithelial cells that is mediated through TLR4-dependent epithelial macrophage crosstalk in intestinal mucosal homeostasis.
Current investigations include:
Cell type specific roles of antigen presenting cells in the regulation of adaptive immunity in the intestine.
Identification of the mechanism underlying TRIF-dependent regulation of Th17 cell plasticity during colitis.
TRIF-dependent regulation of macrophage phagocytosis
- Hyun J, Romero L, Riveron R, Flores C, Kanagavelu S, Chung KD, Alonso A, Sotolongo J, Ruiz J, Manukyan A, Chun S, Singh G, Salas P, Targan SR, Fukata M: Human intestinal epithelial cells express interleukin-10 through Toll-like receptor 4-mediated epithelial-macrophage crosstalk. J Innate Immun, 7(1): 87-101, 2014
- Kanagavelu S, Flores C, Termini JM, Riveron R, Romero L, Chung K, Ruiz J, Hyun J, Yuan X, Dagvadorj J, Fukata M: TIR-domain-containing adapter-inducing interferon-ß (TRIF) regulates Th17-mediated intestinal immunopathology in colitis. Mucosal Immunol, 8(2): 296-306, 2014
- Siefker DT, Echeverry A, Brambilla R, Fukata M, Schesser K, Adkins B: Murine neonates infected with Yersinia enterocolitica develop rapid and robust proinflammatory responses in intestinal lymphoid tissues. Infect. Immun., 82(2): 762-72, 2013
- Hernandez Y, Sotolongo J, Breglio K, Conduah D, Chen A, Xu R, Hsu D, Ungaro R, Hayes LA, Pastorini C, Abreu MT, Fukata M: The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia. BMC Gastroenterol, 10: 82, 2010
- Sotolongo J, España C, Echeverry A, Siefker D, Altman N, Zaias J, Santaolalla R, Ruiz J, Schesser K, Adkins B, Fukata M: Host innate recognition of an intestinal bacterial pathogen induces TRIF-dependent protective immunity. J. Exp. Med., 208(13): 2705-16, 2011
- Sotolongo J, Kanagavelu S, Hyun J, Ruiz J, Fukata M: TRIF mobilizes unique primary defense against Gram-negative bacteria in intestinal interface. Gut Microbes, 3(5): 437-41, 2012