Maya Koronyo-Hamaoui, PhD

Research Scientist, Maxine Dunitz Neurosurgical Institute
Phone:(310) 423-7374

Academic Appointments

Assistant Professor, Neurosurgery
Assistant Professor, Biomedical Sciences

Awards and Activities

DNRCA - CSMC Department of Neurosurgery Collaborative Research Award2013 - 2014
BrightFocus Foundation Alzheimer's Research Award2013
Pioneer in Medicine Award, the Brain Mapping Foundation (Retinal Imaging in AD)2013
The primary award from the Coins for Alzheimer's Research Trust Fund2012
The Alzheimer's Association International Conference (AAIC) 2012 Travel Award2012
Best Research Poster Award & Prize - 1st & 2nd Annual Cedars-Sinai Research Days2010 - 2011
Joan and Jaime Constantiner and the ISPG Travel Awards2004 - 2005
Wolf Fund Excellence Award & Prize, the Sackler School of Medicine Faculty Dean, TAU1996
Summa Cum Laude Master's Degree1995
Cum Laude Bachelors in Science degree1992
Dean's Excellence Award & Prize, the George S. Wise Life Sciences Faculty, Tel-Aviv University (TAU)1992 - 1994
Editorial Board: Public Library of Science (PLoSONE)Current
Member, Society for Neuroscience (SfN)2006
Member: International Society to Advance Alzheimer Research and Treatment (ISTAART)2007
Member: Association for Research in Vision and Ophthalmology (ARVO)2011
Member, Society for Brain Mapping and Therapeutics (SBMT)2011
Member, International Society of Neuroimmunology (ISNI)2012

Research Focus

Identifying and characterizing retinal pathologies specific to neurodegenerative disorders, especially Alzheimer's disease (AD). Investigation of the underling immunological mechanisms to battle AD.

Research Contributions

* First-ever identification and characterization of hallmark pathology of Alzheimer's disease (AD), amyloid-ß protein (Aß) plaques, in the retina of human AD patients, and at early disease stages.
* Development of an innovative method to diagnose AD-pathology through the retina in live subjects; First-ever noninvasive optical retinal imaging of Aß deposits in live rodent models via curcumin labeling.
* First-ever noninvasive monitoring of individual Aß deposit dynamic appearance and clearance in live rodent models following immune-based therapy.
* The discovery that targeted ACE-overexpression in monocytes and microglia drastically attenuated the pathology associated with AD and retained cognitive function in murine models.
* Detection of novel molecular and cellular immune mechanisms essential for attenuating AD-like pathology; Development of immune-modulation therapeutic approaches to resist AD.
* Discovery of a link between genes in the glutamatergic system and genetic predisposition to complex psychiatric disorders, and especially anorexia nervosa.
* Identifying thymic involution as a co-morbidity factor in amyotrophic lateral sclerosis.

Current investigations include:

* Development of an effective immune-based therapy for Alzheimer's disease (AD)
* Investigation of the underlying immunological mechanisms involved in battling AD
* Identification and characterization of retinal pathology and visual dysfunctions specific to AD, in human patients and rodent models
* Investigation of the connection between the retina and the brain in neurodegenerative disorders, in terms of disease biomarkers, progression, and response to immunotherapy
* Investigation of the ability of iPS-derived as well as ACE-overexpressing macrophages to resist amyloid-ß protein

Selected Publications

  1. Bernstein KE, Koronyo Y, Salumbides BC, Sheyn J, Pelissier L, Lopes DH, Shah KH, Bernstein EA, Fuchs DT, Yu JJ, Pham M, Black KL, Shen XZ, Fuchs S, Koronyo-Hamaoui M: Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer's-like cognitive decline. J. Clin. Invest., , 2014
  2. Koronyo Y, Salumbides BC, Black KL, Koronyo-Hamaoui M: Alzheimer's disease in the retina: imaging retinal aß plaques for early diagnosis and therapy assessment. Neurodegener Dis, 10(1-4): 285-93, 2012
  3. Koronyo-Hamaoui M, Koronyo Y, Ljubimov AV, Miller CA, Ko MK, Black KL, Schwartz M, Farkas DL: Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model. Neuroimage, 54 Suppl 1: S204-17, 2010
  4. Koronyo-Hamaoui M, Ko MK, Koronyo Y, Azoulay D, Seksenyan A, Kunis G, Pham M, Bakhsheshian J, Rogeri P, Black KL, Farkas DL, Schwartz M: Attenuation of AD-like neuropathology by harnessing peripheral immune cells: local elevation of IL-10 and MMP-9. J. Neurochem., , 2009
  5. Butovsky O, Koronyo-Hamaoui M, Kunis G, Ophir E, Landa G, Cohen H, Schwartz M: Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proc. Natl. Acad. Sci. U.S.A., 103(31): 11784-9, 2006
  6. Koronyo-Hamaoui M, Danziger Y, Frisch A, Stein D, Leor S, Laufer N, Carel C, Fennig S, Minoumi M, Apter A, Goldman B, Barkai G, Weizman A, Gak E: Association between anorexia nervosa and the hsKCa3 gene: a family-based and case control study. Mol. Psychiatry, 7(1): 82-5, 2002

Lab Information

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