Philip K. Frykman, MD, PhD, MBA, FACS, FAAP

Associate Director, General Pediatric Surgery

Email:philip.frykman@cshs.org
Phone:(310) 423-2331
Fax:(310) 423-5454

Academic Appointments

Associate Professor, Biomedical Sciences
Associate Professor, Academic Affairs
Assistant Clinical Professor, Surgery

Awards and Activities

NIH - K08 Career Development Award2011
Alpha Omega Alpha2001
Medical Scientist Training Program Fellowship1990
Editorial Consultant for European Journal of Pediatric SurgeryCurrent
Reviewer: Journal of PediatricsCurrent
Reviewer: Journal of Pediatric SurgeryCurrent
International Pediatric Endosurgery Group2004
Fellow American College of Surgeons2007
Member American Pediatric Surgical Association2007
Fellow American Academy of Pediatrics (Surgical section)2008

Research Focus

Dr. Frykman's research focuses on identification the genetic, immune and microbial mechanisms leading to complications in children with Hirschsprung disease. The most frequent and serious complication is Hirschsprung-associated enterocolitis (HAEC). His research team developed a surgical mouse model of post-pull-through Hirschsprung-associated enterocolitis, extensively characterizing the enterocolitis in the Ednrb-null mouse thereby establishing a valuable animal model of HAEC that closely mimics that of children with Hirschsprung disease. His lab is currently studying how immune cell trafficking and function may influence development of HAEC. Additionally, Dr. Frykman's lab is exploring the changes in gut bacteria and fungi populations in children who develop HAEC compared with those who do not develop HAEC.

Research Contributions

Leader in discovery of the biological mechanisms of Hirschsprung associated enterocolitis, and application to improve treatment of children with HAEC.

Current investigations include:

Correlative clinical, pathological, genetic, serological, bacterial and fungal microbiome investigations of children HD and HAEC. Cross-species comparison of the Ednrb and Et-3 mouse microbiomes with the human HD microbiome.

Selected Publications

  1. Frykman PK, Short SS: Hirschsprung-associated enterocolitis: prevention and therapy. Semin. Pediatr. Surg., 21(4): 328-35, 2012
  2. Cheng Z, Wang X, Dhall D, Zhao L, Bresee C, Doherty TM, Frykman PK: Splenic lymphopenia in the endothelin receptor B-null mouse: implications for Hirschsprung associated enterocolitis. Pediatr. Surg. Int., 27(2): 145-50, 2011
  3. Cheng Z, Dhall D, Zhao L, Wang HL, Doherty TM, Bresee C, Frykman PK: Murine model of Hirschsprung-associated enterocolitis. I: phenotypic characterization with development of a histopathologic grading system. J. Pediatr. Surg., 45(3): 475-82, 2010
  4. Zhao L, Dhall D, Cheng Z, Wang HL, Doherty TM, Bresee C, Frykman PK: Murine model of Hirschsprung-associated enterocolitis II: Surgical correction of aganglionosis does not eliminate enterocolitis. J. Pediatr. Surg., 45(1): 206-11; discussion 211-2, 2010
  5. Zhao L, Cheng Z, Dhall D, Doherty TM, Frykman PK: A novel corrective pullthrough surgery in a mouse model of Hirschsprung's disease. J. Pediatr. Surg., 44(4): 759-66, 2009
  6. Frykman PK, Brown MS, Yamamoto T, Goldstein JL, Herz J: Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor. Proc. Natl. Acad. Sci. U.S.A., 92(18): 8453-7, 1995

Lab Information