P.K. Shah, MD

Director, Oppenheimer Atherosclerosis Research Ctr, Cardiology

Director, Atherosclerosis Prevention and Mgt Ctr, Cardiology

Email:shahp@cshs.org
Phone:0
Fax:(310) 423-0144

Institute Affiliation

Heart Institute

Academic Appointments

Professor, Medicine

Awards and Activities

Distinguised Scientific Achievement Award, American College of Cardiology2012
James B Herrick Award2008
Annual Laennec Society Lecture2008
Pioneer in Medicine Award2007
Lifetime Acheivement Award2002
Gifted Teacher Award2001
Dean's Award for Excellence in Teaching1990
Shapell and Webb Family Chair in Clinical Cardiology1990

Research Focus

Molecular mechanisms of atherosclerosis and novel therapeutic strategies to prevent and reverse atherosclerosis.

Research Contributions

Discovered the atheroprotective and atheroregressive effects of recombinant mutant apolipoprotein (apo A-I milano) and led its development into a therapeutic strategy.
Developed the concept of immunomodulation of atherosclerosis using oxidized LDL and apo B-100 related peptide antigens in a vaccination strategy.
Established the concept that macrophages and metalloproteinases contribute to plaque rupture and thrombosis.

Current investigations include:

Role of novel genes (Tenascin and Pleotrophin) in atherosclerosis ,plaque neovascularity and intraplaque hemorrhage. Potential role of peritoneum derived progenitor cells and vasculogenesis. Immune modulation of atherosclerosis with Apo B 100 peptides and their potential mechanism of action. Gene transfer of Apo A-I milano using AAV vectors for atherosclerosis modulation. Modulation of atherosclerosis by plant derived Apo A-I milano.

Selected Publications

  1. Sharifi BG, Zeng Z, Wang L, Song L, Chen H, Qin M, Sierra-Honigmann MR, Wachsmann-Hogiu S, Shah PK: Pleiotrophin induces transdifferentiation of monocytes into functional endothelial cells. Arterioscler. Thromb. Vasc. Biol., 26(6): 1273-80, 2006
  2. Wang L, Sharifi BG, Pan T, Song L, Yukht A, Shah PK: Bone marrow transplantation shows superior atheroprotective effects of gene therapy with apolipoprotein A-I Milano compared with wild-type apolipoprotein A-I in hyperlipidemic mice. J. Am. Coll. Cardiol., 48(7): 1459-68, 2006
  3. Michelsen KS, Wong MH, Shah PK, Zhang W, Yano J, Doherty TM, Akira S, Rajavashisth TB, Arditi M: Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc. Natl. Acad. Sci. U.S.A., 101(29): 10679-84, 2004
  4. Chyu KY, Shah PK: Choking off plaque neovascularity: a promising atheroprotective strategy or a double-edged sword?. Arterioscler. Thromb. Vasc. Biol., 27(5): 993-5, 2007
  5. Fredrikson GN, Schiopu A, Berglund G, Alm R, Shah PK, Nilsson J: Autoantibody against the amino acid sequence 661-680 in apo B-100 is associated with decreased carotid stenosis and cardiovascular events. Atherosclerosis, 194(2): e188-92, 2007
  6. Shah PK: Innate immune pathway links obesity to insulin resistance. Circ. Res., 100(11): 1531-3, 2007