Run Yu, PhD

Medical Director, Neuroendocrine Tumor Center
Phone:(310) 423-7647
Fax:(310) 423-0440

Academic Appointments

Assistant Professor, Medicine

Awards and Activities

Genentech Clinical Fellows Travel Grant from Endocrine Society2005
AACR-AstraZeneca Scholar-in-Training Award from the American Association for Cancer Research2001
Knoll Thyroid Research Clinical Fellowship Award from the Endocrine Society1999

Research Focus

Regulation of pancreatic beta cell mass using mouse models and cell culture to understand the humoral and intrinsic beta cell factors that determine beta cell mass.

Research Contributions

Showed that deletion of a cell cycle-regulating gene causes diminished beta cell mass. Found the mechanism is more beta cell apoptosis and senescence.

Current investigations include:

Mechanism of the apoptosis and senescence in beta cells. Role of DNA damage by deletion of a cell cycle-regulating gene.

Selected Publications

  1. Wang Z, Moro E, Kovacs K, Yu R, Melmed S: Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes. Proc. Natl. Acad. Sci. U.S.A., 100(6): 3428-32, 2003
  2. Yu R, Cruz-Soto M, Li Calzi S, Hui H, Melmed S: Murine pituitary tumor-transforming gene functions as a securin protein in insulin-secreting cells. J. Endocrinol., 191(1): 45-53, 2006
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