Shawn Wagner, PhD

Technical Director, Small Animal MRI, Biomedical Imaging Research Institute, Biomedical Sciences
Phone:(310) 423-7519
Fax:(310) 967-0639

Academic Appointments

Assistant Professor, Biomedical Sciences

Awards and Activities

Member, Int'l Society of Magnetic Resonance in Medicine2007
Safety Committee, International Society of Magnetic Resonance in Medicine (ISMRM)2011
Member, American Association of Cancer Research2011

Research Focus

Hyperpolarization is a new and emerging field within magnetic resonance imaging providing enhancement of signal over 10,000 times what is currently available. Our current research utilizes a method of polarization using parahydrogen to transfer the polarization from the hydrogen nuclei to a carbon or nitrogen nucleus with a slower signal decay allowing for in vivo studies, focusing on prostate and breast cancer.

Research Contributions

Defined the pH dependence of hyperpolarizing succinate delivery to tumors and the pH contribution to the chemical shift. Developed the concepts for hyperpolarized spin accounting, a requirement for understanding downstream metabolism.

Current investigations include:

Prostate and breast cancer metabolic research; 15N Choline hyperpolarization; Parahydrogen Induced Polarization Equipment construction and modification; PHIP Biomarkers development and hydrogenation chemical rate catalyst dependency.

Selected Publications

  1. Ross BD, Bhattacharya P, Wagner S, Tran T, Sailasuta N: Hyperpolarized MR imaging: neurologic applications of hyperpolarized metabolism. AJNR. American journal of neuroradiology, 31(1): 24-33, 2009
  2. Bhattacharya P, Chekmenev EY, Reynolds WF, Wagner S, Zacharias N, Chan HR, Bünger R, Ross BD: Parahydrogen-induced polarization (PHIP) hyperpolarized MR receptor imaging in vivo: a pilot study of 13C imaging of atheroma in mice. NMR Biomed, 24(8): 1023-8, 2011

Lab Information