Shlomo Melmed, M.B., Ch.B., MACP, FRCP

Senior Vice President, Academic Affairs

Dean of the Medical Faculty

Director, Burns and Allen Research Institute

Email:melmed@csmc.edu
Phone:(310) 423-4691
Fax:(310) 423-0119

Institute Affiliation

Burns and Allen Research Institute

Academic Appointments

Professor, Medicine

Awards and Activities

Transatlantic Medal, Society of Endocrinology2010
Endocrine Regulation Prize, Fondation IPSEN2010
Endocrine Society Clinical Investigator Award2004
Helene A. and Philip E. Hixon Chair in Investigative Medicine2002
Royal Society of Medicine, Clinical Endocrinology Trust Medal1994
Editor: Williams Textbook of EndocrinologyCurrent
Editor: DeGroot and Jameson EndocrinologyCurrent
Editor-in-Chief: PituitaryCurrent
Editor-in-Chief: Endocrinology1992 - 1997
President, Pituitary Society2002
President, International Society of Endocrinology2004 - 2008

Research Focus

Molecular pathogenesis of pituitary tumors, and pituitary receptor signaling. Employ molecular, cellular, transgenic animal, and human tissue models to understand the biology of these commonly encountered hormone-secreting adenomas. Test pituitary receptor signaling to develop novel peptide analog treatments for these tumors secreting growth hormone, prolactin, ACTH or gonadotropins.

Research Contributions

Leader in the discovery of pituitary cell cycle genes, and developed application of novel peptide treatments for endocrine tumors.

Current investigations include:

Transgenic models of pituitary tumors. Pituitary receptor signaling. Pituitary progenitor cells. Pituitary tumor therapeutic outcomes.

Selected Publications

  1. Murray RD, Kim K, Ren SG, Chelly M, Umehara Y, Melmed S: Central and peripheral actions of somatostatin on the growth hormone-IGF-I axis. J. Clin. Invest., 114(3): 349-56, 2004
  2. Ben-Shlomo A, Wawrowsky KA, Proekt I, Wolkenfeld NM, Ren SG, Taylor J, Culler MD, Melmed S: Somatostatin receptor type 5 modulates somatostatin receptor type 2 regulation of adrenocorticotropin secretion. J. Biol. Chem., 280(25): 24011-21, 2005
  3. Melmed S: Medical progress: Acromegaly. N. Engl. J. Med., 355(24): 2558-73, 2006
  4. Chesnokova V, Zonis S, Kovacs K, Ben-Shlomo A, Wawrowsky K, Bannykh S, Melmed S: p21(Cip1) restrains pituitary tumor growth. Proc. Natl. Acad. Sci. U.S.A., 105(45): 17498-503, 2008
  5. Liu NA, Jiang H, Ben-Shlomo A, Wawrowsky K, Fan XM, Lin S, Melmed S: Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (CDK) inhibitor. Proc. Natl. Acad. Sci. U.S.A., 108(20): 8414-9, 2011
  6. Melmed S: Pathogenesis of pituitary tumors. Nat Rev Endocrinol, 7(5): 257-66, 2011

Lab Information