Timothy Crother, Ph.D.

Research Scientist, Immunology Research

Research Scientist, PD Infectious Disease, Allergy & Immunology

Phone:(310) 423-7970

Academic Appointments

Assistant Professor, Pediatrics

Awards and Activities

International travel grant1997
NIH Genetics Training Grant, Indiana University.1997 - 1998
NIH Genetics Training Grant, Indiana University.1996 - 1997
American Society for Microbiology2002

Research Focus

Immunology and pathogenesis of various diseases of the lung, including infections and asthma.

Research Contributions

Key researcher in the field of plasmacytoid dendritic cell responses to bacterial infections. Major contributor to the understanding of innate immune responses to Chlamydia pneumonia infections.

Current investigations include:

Plasmacytoid dendritic cell responses to bacterial infections in the lung. The role of autophagy in Chlamydia pneumonia infection. Innate immune responses during infection induced asthma and fibrosis.

Selected Publications

  1. Crother TR, Ma J, Jupelli M, Chiba N, Chen S, Slepenkin A, Alsabeh R, Peterson E, Shimada K, Arditi M: Plasmacytoid dendritic cells play a role for effective innate immune responses during Chlamydia pneumoniae infection in mice. PLoS ONE, 7(10): e48655, 2012
  2. Jones HD, Crother TR, Gonzalez-Villalobos RA, Jupelli M, Chen S, Dagvadorj J, Arditi M, Shimada K: The NLRP3 inflammasome is required for the development of hypoxemia in LPS/mechanical ventilation acute lung injury. Am. J. Respir. Cell Mol. Biol., 50(2): 270-80, 2014
  3. Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S, Ramanujan VK, Wolf AJ, Vergnes L, Ojcius DM, Rentsendorj A, Vargas M, Guerrero C, Wang Y, Fitzgerald KA, Underhill DM, Town T, Arditi M: Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity, 36(3): 401-14, 2012
  4. Crother TR, Schröder NW, Karlin J, Chen S, Shimada K, Slepenkin A, Alsabeh R, Peterson E, Arditi M: Chlamydia pneumoniae infection induced allergic airway sensitization is controlled by regulatory T-cells and plasmacytoid dendritic cells. PLoS ONE, 6(6): e20784, 2011
  5. Schröder NW, Crother TR, Naiki Y, Chen S, Wong MH, Yilmaz A, Slepenkin A, Schulte D, Alsabeh R, Doherty TM, Peterson E, Nel AE, Arditi M: Innate immune responses during respiratory tract infection with a bacterial pathogen induce allergic airway sensitization. J. Allergy Clin. Immunol., 122(3): 595-602.e5, 2008