Angiotensin-Converting Enzyme

Cedars-Sinai researchers are identifying the factors that contribute to hypertension and control normal blood pressure as well as the role of the renin-angiotensin system (RAS) under normal conditions and disease.

Preclinical Research

Using genetic models in mice, Cedars-Sinai researchers are investigating the basic physiology and biochemistry of RAS and the possibility of manipulating this system as a means of increasing immune resistance. Their research is showing that RAS contributes to blood pressure control, renal development and function, reproduction, immune response and hematopoiesis.

They are also studying the two important areas of RAS: the angiotensin II receptor and the angiotensin-converting enzyme (ACE).

ACE
In mouse models, researchers are investigating important functional differences between the two ACE domains, which have major implications because of the development of prototypical ACE inhibitors specific to each ACE catalytic domain.


Angiotensin II receptor
A series of mouse models with a modified ACE gene are being created, focusing on the physiological role of ACE in individual tissue types, such as the heart and kidney. These animal models are addressing the role of ACE apart from blood pressure control. It's being learned that these processes contribute to the overall production of angiotensin II.


Labs


Collaborations

Researcher Maya Koronyo-Hamaoui, PhD, is working at the Maxine Dunitz Neurosurgical Institute to identify the role of ACE in Alzheimer's disease.

George Liu, MD, PhD, associate director of the Infectious and Immunological Diseases Research Center, is investigating the use of the ACE inhibitor lisinopril as a strategy to treat infections caused by antibiotic-resistant pathogens.