Interventional Cardiology

Preclinical Research

In preclinical research projects, investigators are studying cellular pathways governing valve degeneration and potential molecular targets for drug therapy. Investigators also evaluate percutaneous intervention technologies that translate into clinical treatment for structural heart disease.

Clinical Research

Investigators participate in multiple national clinical trials and investigations using devices aiming to prolong survival and improve patients' quality of life after surgery. Clinical research projects primarily focus on the treatment of structural heart disease, investigational interventions for aortic stenosis, mitral and pulmonic valve regurgitation, ischemic heart disease and patent foramen oval.

Aortic Valve

  • PARTNER II Trial: Transcatheter Aortic Valve Implantation Sapien XT and Sapien 3 Valve
  • Surtavi Corevalve on Intermediate Risk
  • Reprise III, Lotus: Repositionable Percutaneous Replacement of Stenotic Aortic Valve Through Implantation of Lotus Valve System
  • The Sentinel Study: Cerebral Protection in Transcatheter Aortic Valve Replacement
  • SALUS Trial: Transcatheter Aortic Valve Replacement System – a US Pivotal Trial: the safety and effectiveness of the direct-flow medical transcatheter aortic valve system in patients at extreme surgical risk with severe aortic stenosis
  • Portico Resheathable Transcatheter Aortic Valve System US IDE Trial

Mitral Valve

  • Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation
    • Principal Investigator: Saibal Kar, MD
  • Neovasc Tiara Mitral Valve: Early Feasibility Study of the Neovasc Tiara Transapical Delivery System (TIARA-1)

Pulmonic Valve

Ischemic Heart Disease

Patent Foramen Ovale (PFO)

  • GORE HELEX Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke or Imaging Confirmed TIA in Patients With Patent Foramen Ovale (PFO)
    • Principal investigator: Saibal Kar, MD


Interventional cardiology researchers collaborate with Cardiac Surgery, Neurology and Heart Failure.