Biobehavioral Research Core

The Biobehavioral Research Core is a subdivision of the Animal Models Core and assists in all aspects of behavioral testing in rodents, including the execution of behavioral tests, the development of experimental designs, and the submission of IACUC protocols, as well as analysis of data and preparation of scientific reports. Behavioral testing in rodents ranges from the assessment of general health and neurological function (i.e., sensory and motor function) to the measurement of complex behaviors such as social interaction, memory and learning.

The Biobehavioral Research Core provides assistance for the development of testing schedules with standard and/or custom batteries of behavioral tests.

 

Standard neurobehavioral assessment

Assessments are available to study animal models of human diseases and disorders, such as Alzheimer’s disease, Lou Gehrig’s disease (ALS), Huntington’s disease, autism, chronic pain, and drug abuse, and to study disease-specific behavioral effects of treatment/therapies.

 

Behavioral phenotyping

Wide-range screening of behavior to uncover neurobehavioral deficits in transgenic animals, followed by in-depth focused behavioral assessments with customized batteries of tests.

 

Undesirable behavioral effects of drugs and biologics (gene, vaccine and stem cell therapies)

In vivo pharmacology safety studies including standard (sensory and motor reflex responses, motor activity, and coordination) and custom (sedation, tremors, pain, mild cognitive impairment, and addictive behavior) batteries of behavioral tests to define the possible behavioral side effects of a treatment.

Best practices observed in the Biobehavioral Research Core ensure the quality and reliability of the preclinical behavioral assessments with the possibility of implementing non-GLP protocols which satisfy the requirements of the FDA.