ALS iPSC Lines

Sponsored by Cedars-Sinai Board of Governors, ALS Association, National Institute of Neurological Disorders and Stroke, NIH LINCS Program, NeuroLINCS

If you would like to request any of the cell lines listed below, please contact the iPSC Core at ipsccore@cshs.org.

Control Lines

Diseased Lines

Healthy Controls ALS-C9orf72
ALS-SOD1
Sporadic ALS

 

Healthy Controls


iPSC Line

Source Tissue

Clinical remarks

Mutation

Race

Gender

Age at Sampling

CS03iCTR-NTnxx PBMCs (non-T) Clinically normal and healthy volunteer Unknown ASIAN Male 34
CS179iCTR-NTnxx PBMCs (non-T) Clinically normal and healthy volunteer Unknown CAUC Male 57
CS201iCTR-NTnxx PBMCs (non-T) Clinically normal and healthy volunteer Unknown CAUC Female 56
CS80iCTR-Tnxx PBMCs (T-Cell) Clinically normal and healthy volunteer Unknown CAUC Female 48
CS00iCTR-nxx Fibroblast Clinically normal and healthy volunteer Unknown AA Male 6
CS88iCTR-nxx Fibroblast Clinically normal and healthy volunteer Unknown CAUC Male 57
CS25iCTR-18nxx Fibroblast Clinically normal and healthy volunteer Unknown CAUC Male 76
CS83iCTR-33nxx Fibroblast Clinically normal and healthy volunteer Unknown CAUC Female 21
CS71iCTR-20nxx Fibroblast Clinically normal and healthy volunteer Unknown CAUC Female 61
CS14iCTR-nxx Fibroblast Clinically normal and healthy volunteer Unknown CAUC Female 30-35
CS03iCTR-nxx Fibroblast Clinically normal and healthy volunteer Unknown CAUC Male N/A

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ALS-C9orf72


iPSC Line

Source Tissue

Clinical remarks

Mutation

Race

Gender

Age at Sampling

CS28iALS-C9nxx Fibroblast Age of onset: 46; Site of onset: left upper extremity. C9orf72 hexanucleotide repeat expansion (6-8kb expanded allele) Male 47
CS29iALS-C9nxx Fibroblast Age of onset: 46; Site of onset: left upper extremity. C9ORF72  hexanucleotide repeat expansion (6-8kb expanded allele) CAUC Male 47
CS30iALS-C9nxx Fibroblast  Left Extremity Age of onset: 51; 29 mo disease duration, Site of onset: Bulbar, Mildly decreased verbal fluency.  C9ORF72 hexanucleotide repeat expansion (2.7kb expanded allele) CAUC Female 51
CS52iALS-C9nxx Fibroblast ALS, Age of onset: 57; mo disease duration, 48; Site of onset: Left upper extremity.  C9orf72 hexanucleotide repeat expansion (6-8 kb) Male 49
CS58iALS-C9nxx PBMC (non-T) Site of onset_ Left Extremity C9ORF72 CAUC Male 61
CS134iALS-C9NTn1 PBMCs (non-T) Site of onset: Left Extremity C9ORF72 CAUC Male 49

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ALS-SOD1


iPSC Line

Source Tissue

Clinical remarks

Mutation

Race

Gender

Age at Sampling

CS04iALS-SOD1H44Rn3 Fibroblast Site of onset: Respiratory SOD1 H44R CAUC Female 36
CS07iALS-SOD1A4Vn7 Fibroblast   SOD1 A4V CAUC Female 40
CS11iALS-SOD1I114Tn10 Fibroblast   SOD1 I114T CAUC Male 57
CS22iALS-SOD1I114Tn2 Fibroblast Site of onset: Spinal SOD1 I114T CAUC Male 51
CS24iALS-SOD1E50Kn9 Fibroblast Site of onset: Spinal SOD1 E50K CAUC Female 49
CS53iALS-SOD1A4VNTn3 PBMC (non-T) Site of onset: Left Extremity SOD1 A4V CAUC Male 35
CS118iALS-SOD1I113Tnxx Fibroblast SOD1 I113T Female 73
CS367iALS-SOD1A89Vnxx Fibroblast SOD1 A89V Male 45

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Sporadic ALS


iPSC Line

Source Tissue

Clinical remarks

Mutation

Race

Gender

Age at Sampling

CS14isALS-Tn16 PBMCs (T cell) Sporadic ALS, Site of onset: NA Unknown CAUC Male 42
CS36isALS-nxx Lymphoblastoid cell line Sporadic ALS Female 32
CS46isALS-nxx Lymphoblastoid cell line Sporadic ALS Male 37
CS98iALS-Tnxx PBMC Sporadic Female 64
CS138isALS-Tnxx PBMC Sporadic Male 66
CS152isALS-Tnxx PBMC Sporadic Female 68

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