Publications

See a complete PubMed list of publications by Dolores Di Vizio, MD, PhD.

Selected Key Publications

Vagner T, Spinelli C, Minciacchi VR, Balaj L, Zandian M, Conley A, Zijlstra A, Freeman MR, Demichelis F, De S, Posadas EM, Tanaka H, Di Vizio D. Large extracellular vesicles carry most of the tumour DNA circulating in prostate cancer patient plasma. J Extracell Vesicles. 2018 Aug 7;7(1):1505403. https://www.tandfonline.com/doi/full/10.1080/20013078.2018.1505403.

Zijlstra A, Di Vizio D. Size matters in nanoscale communication. Nat Cell Biol. 2018 Mar;20(3):228–230. https://www.nature.com/articles/s41556-018-0049-8.

Soekmadji C, Hill AF, Wauben MH, Buzás EI, Di Vizio D, Gardiner C, Lötvall J, Sahoo S, Witwer KW. Towards mechanisms and standardization in extracellular vesicle and extracellular RNA studies: results of a worldwide survey. J Extracell Vesicles. 2018 Oct 24;7(1):1535745. https://www.tandfonline.com/doi/full/10.1080/20013078.2018.1535745.

Reis-Sobreiro M, Chen JF, Novitskaya T, You S, Morley S, Steadman K, Kaur Gill NK, Eskaros A, Rotinen M, Chu CY, Chung LWK, Tanaka H, Yang W, Knudsen BS, Tseng HR, Rowat AC, Posadas EM, Zijlstra A, Di Vizio D, Freeman MR. Emerin deregulation links nuclear shape instability to metastatic potential. Cancer Res. 2018 Nov 1;78(21):6086-6097. http://cancerres.aacrjournals.org/content/78/21/6086.

Minciacchi VR, Zijlstra A, Rubin MA, Di Vizio D. Extracellular vesicles for liquid biopsy in prostate cancer: where are we and where are we headed? Prostate Cancer Prostatic Dis. 2017 Sep;20(3):251–258. https://www.nature.com/articles/pcan20177.

Minciacchi VR, Spinelli C, Reis-Sobreiro M, Cavallini L, You S, Zandian M, Li X, Chiarugi P, Adam RM, Posadas EM, Viglietto G, Freeman MR, Cocucci E, Bhowmick NA, Di Vizio D. MYC mediates large oncosome-induced fibroblast reprogramming in prostate cancer. Cancer Res. 2017 May 1;77(9):2306-2317. http://cancerres.aacrjournals.org/content/77/9/2306.

Conley A, Minciacchi VR, Lee DH, Knudsen BS, Karlan BY, Citrigno L, Viglietto G, Tewari M, Freeman MR, Demichelis F, Di Vizio D. High-throughput sequencing of two populations of extracellular vesicles provides an mRNA signature that can be detected in the circulation of breast cancer patients. RNA Biol. 2017 Mar 4;14(3):305-316. https://www.tandfonline.com/doi/full/10.1080/15476286.2016.1259061.

Minciacchi VR, Freeman MR, Di Vizio D. Extracellular vesicles in cancer: exosomes, microvesicles and the emerging role of large oncosomes. Semin Cell Dev Biol. 2015 Apr;40:41-51. https://www.sciencedirect.com/science/article/pii/S1084952115000373.

Minciacchi VR, You S, Spinelli C, Morley S, Zandian M, Aspuria P, Cavallini L, Ciardiello C, Reis Sobreiro M, Morello M, Kharmate G, Jang SC, Kim DK, Hosseini-Beheshti E, Tomlinson Guns E, Gleave M, Gho YS, Mathivanan S, Yang W, Freeman MR, Di Vizio D. Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles. Oncotarget. 2015 May 10;6(13):11327–11341. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=3598.

Kim OY, Choi SJ, Jang SC, Park KS, Kim SR, Choi JP, Lim JH, Lee SW, Park J, Di Vizio D, et al. Bacterial protoplast-derived nanovesicles as vaccine delivery system against bacterial infection. Nano Lett. 2015 Jan 14;15(1):266-274. https://pubs.acs.org/doi/10.1021/nl503508h.

Morello M, Minciacchi VR, de Candia P, Yang J, Posadas E, Kim H, Griffiths D, Bhowmick N, Chung LW, Gandellini P, Freeman MR, Demichelis F, Di Vizio D. Large oncosomes mediate intercellular transfer of functional microRNA. Cell Cycle. 2013 Nov 15;12(22):3526-3536. https://www.tandfonline.com/doi/abs/10.4161/cc.26539.

Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW, Burga LN, Xie J, Jurczak MJ, DePinho RA, Clish CB, Jacks T, Kibbey RG, Wulf GM, Di Vizio D, et al. PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell. 2013 Oct 10;155(2):397-409. https://www.cell.com/cell/fulltext/S0092-8674(13)01162-8.

Ayala G, Morello M, Frolov A, You S, Li R, Rosati F, Bartolucci G, Danza G, Adam RM, Thompson TC, Lisanti MP, Freeman MR, Di Vizio D. Loss of caveolin-1 in prostate cancer stroma correlates with reduced relapse-free survival and is functionally relevant to tumour progression. J Pathol. 2013 Sep;231(1):77-87. https://onlinelibrary.wiley.com/doi/abs/10.1002/path.4217.

Di Vizio D, Morello M, Dudley AC, Schow PW, Adam RM, Morley S, Mulholland D, Rotinen M, Hager MH, Insabato L, et al. Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease. Am J Pathol. 2012 Nov;181(5):1573-1584. https://ajp.amjpathol.org/article/S0002-9440(12)00600-1/fulltext.

Di Vizio D, Kim J, Hager MH, Morello M, Yang W, Lafargue CJ, True LD, Rubin MA, Adam RM, Beroukhim R, et al. Oncosome formation in prostate cancer: association with a region of frequent chromosomal deletion in metastatic disease. Cancer Res. 2009 Jul 1;69(13):5601-5609. http://cancerres.aacrjournals.org/content/69/13/5601.