The Gonzalez Neurovascular Laboratory focuses on discovering, developing and translating novel forms of treatment for cerebrovascular disorders, derived from understanding and applying the mechanisms of angiogenesis as therapeutic targets.
Angiogenesis is a fundamental process in maintaining, remodeling and repairing tissues after injury. Angiogenesis has been a focus of research in tumor pathology, and the understanding of its complex mechanisms has led to the development of novel, effective antitumoral agents. Despite advances, the role of angiogenesis in cerebral ischemic disorders is not well understood. Our basic science, translational and clinical research centers on synergistic projects to elucidate the mechanisms of angiogenesis, with the ultimate goal of prevention and repair after cerebral ischemia, intracranial atherosclerosis and other arterial steno-occlusive disorders.
Current investigations in the Gonzalez Lab include:
- Evaluation and application of synangiosis, a process by which collaterals are formed to ischemic territories by apposition of vessels from the extracranial circulation to cerebral ischemic tissue
- Identification and characterization of the circulating profiles of cytokines involved in innate collateral formation, protection from stroke, and post-ischemic repair
- Development of new therapeutic strategies to enhance collateral vessel growth to hypoxic areas of the brain
The Gonzalez Laboratory is affiliated with the Cedars-Sinai Neurosurgery Department.