Lawrenson Laboratory

Research in the Lawrenson Laboratory focuses on the interplay between the transcriptome and the epigenome in ovarian cancer development and progression.

Epithelial ovarian cancer is the most lethal gynecological cancer in developed countries, and there is a critical need to identify novel diagnostic and prognostic biomarkers and therapeutic targets for this disease. While the majority of translational research focuses on proteins and protein-coding genes, research in the Lawrenson Laboratory explores the pathways and mechanisms upstream of the genes deregulated in cancer, as a novel approach to identifying targetable vulnerabilities in cancer. The idea is that by understanding how cancer genes become deregulated we might be better equipped to design rational and more potent approaches to disease treatment. The Lawrenson Lab has a particular focus on the role of long noncoding RNAs that become deregulated during ovarian cancer development, and in studying the role of specific transcription factors, such as PAX8, to glean insight into the histotype-specific cellular origins of this disease.

The Lawrenson Laboratory is affiliated with the Samuel Oschin Comprehensive Cancer Institute and Women's Cancer Program.

Immunofluorescent staining of monolayer cultured cells

Immunofluorescent staining of three-dimensional ovarian cancer cell models