Publications

See a complete PubMed list of publications by Julia Ljubimova, MD, PhD.


Selected Key Publications

Ding H, Gangalum PR, Galstyan A, Fox I, Patil R, Hubbard P, Murali R, Ljubimova JY, Holler E. HER2-positive breast cancer targeting and treatment by a peptide-conjugated mini nanodrug. 2017, Nanomedicine. 2017 Feb;13(2):631-639. http://www.nanomedjournal.com/article/S1549-9634(16)30103-4/fulltext.

Anchordoquy TJ, Barenholz Y, Boraschi D, Chorny M, Decuzzi P, Dobrovolskaia MA, Farhangrazi ZS, Farrell D, Gabizon A, Ghandehari H, Godin B, La-Beck NM, Ljubimova J, et al. Mechanisms and barriers in cancer nanomedicine: addressing challenges, looking for solutions. ACS Nano. 2017 Jan 24;11(1):12-18. http://pubs.acs.org/doi/10.1021/acsnano.6b08244.

Ding H, Fox I, Patil R, Galstyan A, Black KL, Ljubimova JY, Holler E. Polymalic acid tritryptophan copolymer interacts with lipid membrane resulting in membrane solubilization. J Nanomater. 2017;2017. pii: 4238697. https://www.hindawi.com/journals/jnm/2017/4238697/.

Chou ST, Patil R, Galstyan A, Gangalum PR, Cavenee WK, Furnari FB, Ljubimov VA, Chesnokova A, Kramerov AA, Ding H, Falahatian V, Mashouf L, Fox I, Black KL, Holler E, Ljubimov AV, Ljubimova JY. Simultaneous blockade of interacting CK2 and EGFR pathways by tumor-targeted nanobioconjugates increases therapeutic efficacy against glioblastoma multiforme. J Control Release. 2016 Dec 28;244(Pt A):14-23. http://www.sciencedirect.com/science/article/pii/S0168365916311476?via%3Dihub.

Patil R, Ljubimov AV, Gangalum PR, Ding H, Portilla-Arias J, Wagner S, Inoue S, Konda B, Rekechenetskiy A, Chesnokova A, Markman JL, Ljubimov VA, Li D, Prasad RS, Black KL, Holler E, Ljubimova JY. MRI virtual biopsy and treatment of brain metastatic tumors with targeted nanobioconjugates. ACS Nano. 2015;9(5):5594-5608. http://pubs.acs.org/doi/abs/10.1021/acsnano.5b01872.

Patil R, Gangalum PR, Wagner S, Portilla-Arias J, Ding H, Rekechenetskiy A, Konda B, Inoue S, Black KL, Ljubimova JY, Holler E. Curcumin targeted, polymalic acid-based MRI contrast agent for the detection of Aβ plaques in Alzheimer's disease. Macromol Biosci. 2015;15(9):1212-1217. http://onlinelibrary.wiley.com/doi/10.1002/mabi.201500062/abstract.

Hsu BB, Jamieson KS, Hagerman SR, Holler E, Ljubimova JY, Hammond PT. Ordered and kinetically discrete sequential protein release from biodegradable thin films. Angew Chem Int Ed Engl. 2014 Jul 28;53(31):8093-8098. http://onlinelibrary.wiley.com/doi/10.1002/anie.201403702/full.

Ljubimova JY, Ding H, Portilla-Arias J, Patil R, Gangalum PR, Chesnokova A, Inoue S, Rekechenetskiy A, Nassoura T, Black KL, Holler E. Polymalic acid-based nano biopolymers for targeting of multiple tumor markers: an opportunity for personalized medicine? J Vis Exp. 2014 Jun 13;(88). http://www.jove.com/video/50668/polymalic-acid-based-nano-biopolymers-for-targeting-multiple-tumor.

Ljubimova JY, Portilla-Arias J, Patil R, Ding H, Inoue S, Markman JL, Rekechenetskiy A, Konda B, Gangalum PR, Chesnokova A, Ljubimov AV, Black KL, Holler E. Toxicity and efficacy evaluation of multiple targeted polymalic acid conjugates for triple-negative breast cancer treatment. J Drug Target. 2013 Dec;21(10):956-967. http://informahealthcare.com/doi/abs/10.3109/1061186X.2013.837470.

Ljubimova JY, Kleinman MT, Karabalin NM, Inoue S, Konda B, Gangalum P, Markman JL, Ljubimov AV, Black KL. Gene expression changes in rat brain after short and long exposures to particulate matter in Los Angeles basin air: comparison with human brain tumors. Exp Toxicol Pathol. 2013 Nov;65(7-8):1063-1071. http://www.sciencedirect.com/science/article/pii/S0940299313000547.

Ding H, Helguera G, Rodríguez JA, Markman J, Luria-Pérez R, Gangalum P, Portilla-Arias J, Inoue S, Daniels-Wells TR, Black K, Holler E, Penichet ML, Ljubimova JY. Polymalic acid nanobioconjugate for simultaneous immunostimulation and inhibition of tumor growth in HER2/neu-positive breast cancer. J Control Release. 2013 Nov 10;171(3):322-329. http://www.sciencedirect.com/science/article/pii/S0168365913003350.

Markman JL, Rekechenetskiy A, Holler E, Ljubimova JY. Nanomedicine therapeutic approaches to overcome cancer drug resistance. Adv Drug Deliv Rev. 2013 Nov;65(13-14):1866-1879. http://www.sciencedirect.com/science/article/pii/S0169409X13002329.

Brennan CW, Verhaak RG, McKenna A, Campos B, Noushmehr H, Salama SR, Zheng S, Chakravarty D, Sanborn JZ, Berman SH, Ljubimova JY, et al, TCGA Research Network. The somatic genomic landscape of glioblastoma. Cell. 2013 Oct 10;155(2):462-477. http://www.cell.com/cell/abstract/S0092-8674(13)01208-7.

Ljubimova JY, Holler E. Biocompatible nanopolymers: the next generation of breast cancer treatment? Nanomedicine (Lond). 2012 Oct;7(10):1467-1470. http://www.futuremedicine.com/doi/abs/10.2217/nnm.12.115.

Patil R, Portilla-Arias J, Ding H, Konda B, Rekechenetskiy A, Inoue S, Black KL, Holler E, Ljubimova JY. Cellular delivery of doxorubicin via pH-controlled hydrazone linkage using multifunctional nano vehicle based on poly(β-L-malic acid). Int J Mol Sci. 2012;13(9):11681-11693. http://www.mdpi.com/1422-0067/13/9/11681.

Inoue S, Patil R, Portilla-Arias J, Ding H, Konda B, Espinoza A, Mongayt D, Markman JL, Elramsisy A, Phillips HW, Black KL, Holler E, Ljubimova JY. Nanobiopolymer for direct targeting and inhibition of EGFR expression in triple negative breast cancer. PLOS One. 2012;7(2):e31070. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0031070.

Inoue S, Ding H, Portilla-Arias J, Hu J, Konda B, Fujita M, Espinoza A, Suhane S, Riley M, Gates M, Patil R, Penichet ML, Ljubimov AV, Black KL, Holler E, Ljubimova JY. Polymalic acid-based nanobiopolymer provides efficient systemic breast cancer treatment by inhibiting both HER2/neu receptor synthesis and activity. Cancer Res. 2011 Feb 15;71(4):1454-1464. http://cancerres.aacrjournals.org/content/71/4/1454.