The Lu Laboratory has multiple research programs that are focused primarily on mechanisms and treatments of liver injury, fibrosis and cancer. Two molecules that we are most interested in are glutathione (GSH) and S-adenosylmethionine (SAMe). GSH is a key anti-oxidant that protects our cells. Recent studies in the Lu Lab show that GSH synthesis is impaired in multiple forms of liver injury, including fibrosis. SAMe is the principal biological methyl donor and patients with liver disease have reduced hepatic SAMe level. The Lu Laboratory has shown that chronic SAMe depletion in the liver results in liver cancer development in mice. Their goal is to understand how the synthesis of these molecules is regulated and why they become dysregulated in liver disease. Team members in the Lu Lab hope results from their studies will pave the way for novel treatments of liver diseases and prevention of liver cancer.
The Lu Laboratory is affiliated with the Cedars-Sinai Department of Medicine and the Division of Gastroenterology.