See a complete PubMed list of publications by Patrick Lyden, MD.

Selected Key Publications

Schlick KH, Hemmen TM, Lyden PD. Seizures and meperidine: overstated and underutilized. Ther Hypothermia Temp Manag. 2015 Jun 18. [Epub ahead of print.]

Shen XZ, Li Y, Li L, Shah KH, Bernstein KE, Lyden P, Shi P. Microglia participate in neurogenic regulation of hypertension. Hypertension. 2015;66(2):309-316.

Lyden P. Why don't more patients receive intravenous rt-PA for acute stroke? Expert Rev Neurother. 2015;15(6):571-574.

Shih AY, Rühlmann C, Blinder P, Devor A, Drew PJ, Friedman B, Knutsen PM, Lyden PD, Matéo C, Mellander L, et al. Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture. Microcirculation. 2015;22(3):204-218.;jsessionid=4548F9C6D64EB38334FF224D2A1A6193.f02t03.

Bai J, Lyden PD. Revisiting cerebral postischemic reperfusion injury: new insights in understanding reperfusion failure, hemorrhage, and edema. Int J Stroke. 2015;10(2):143-152.

Rajput PS, Lyden PD, Chen B, Lamb J, Pereira B, Lamb A, Zhao L, Lei IF, Bai J. Protease activated receptor-1 mediates cytotoxicity during ischemia using in vivo and in vitro models. Neuroscience. 2014;281(5):229-240.

Lyden P, Pereira B, Chen B, Zhao L, Lamb J, Lei IF, Rajput P. Direct thrombin inhibitor argatroban reduces stroke damage in two different models. Stroke. 2014;45(3):896-899.

Wang Y, Zhao Z, Chow N, Rajput PS, Griffin JH, Lyden PD, Zlokovic BV. Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats. Stroke. 2013;44(12):3529-3536.

Van Winkle JA, Chen B, Lei IF, Pereira B, Rajput PS, Lyden PD. Concurrent middle cerebral artery occlusion and intra-arterial drug infusion via ipsilateral common carotid artery catheter in the rat. J Neurosci Methods. 2013;213(1):63-69.

Chen B, Friedman B, Whitney MA, Winkle JA, Lei IF, Olson ES, Cheng Q, Pereira B, Zhao L, Tsien RY, Lyden PD. Thrombin activity associated with neuronal damage during acute focal ischemia. J Neurosci. 2012;32(22):7622-7631.

Chen B, Cheng Q, Yang K, Lyden PD. Thrombin mediates severe neurovascular injury during ischemia. Stroke. 2010;41(10):2348-2352.

Friedman B, Schachtrup C, Tsai PS, Shih AY, Akassoglou K, Kleinfeld D, Lyden PD. Acute vascular disruption and aquaporin 4 loss after stroke. Stroke. 2009;40(6):2182-2190.