Research Areas

Currently, the Marbán Laboratory is using biologically based therapies for cardiac regeneration and biological pacemakers. All lab members have a specific role in conducting their research that will enable the Marbán Lab to translate their work from the bench to bedside. The research using cardiosphere-derived stem cells (CDCs) has demonstrated cells that are better in their functional repair capacity and in their angiogenic ability to secrete favorable paracrine factors, which other cells currently in clinical use do not. The Marbán Laboratory is now studying various methods of delivering the cells and determining the immunogenicity of allogeneic stem cells in small and large animal models.


Infiltrating leukocytes (CD45+) within the myocardium two days following myocardial infarction. (de Couto G, Marbán E. Unpublished.)


Activation of Wnt signaling by Wnt3a protein or CHIR-99021 (a GSK-3β inhibitor) inhibits voltage-gated sodium current in rat ventricular myocytes. (Liang W, Cho HC, Marbán E. Journal of Physiology 2015. In Press.)


Allogeneic cardiosphere-derived cells (CDCs) attenuate infarct and no-reflow size. Representative transverse cardiac slices stained with gentian violet and 2,3,5-triphenyl tetrazolium chloride. (A) Area at risk (AAR; as % of left ventricular (LV); (B) infarct size (IS; as % of AAR); (C) and IS (as % of LV); (D) at 48 hours postintervention. Representative transverse cardiac slices stained with thioflavin-T under ultraviolet light (E). No-reflow area (as % of AAR) 48 hours postintervention (F). P value is the result of Kruskal–Wallis test. *P<0.05 between 2 groups. MVO indicates microvascular obstruction. (Kanazawa H et al. Cellular post-conditioning: allogeneic cardiosphere-derived cells reduce infarct size and attenuate microvascular obstruction when administered after reperfusion in pigs with acute myocardial infarction. Circ Heart Fail. 2015;8(2):322-332.