Orsulic Laboratory

Our research involves studying the mechanisms by which genetic alterations contribute to cancer initiation and metastatic progression; identifying molecular markers for early cancer detection; generating suitable pre-clinical models for testing therapies that target specific biochemical pathways; and modeling the development of drug resistance to targeted therapies.

We use diverse technologies such as genomic and expression profiling of human tissues, cell and organ culture systems, and Cre-lox and tetracycline-inducible genetically engineered mice that recapitulate the development and pathophysiological manifestations of human cancers.

The Orsulic Laboratory is affiliated with the Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute and Obstetrics and Gynecology Department.